One-pot synthesis of 3,4,5-trisubstituted 1,2,4-triazoles via the addition of hydrazides to activated secondary amides

Autor: Inna S. Khazhieva, André B. Charette, William S. Bechara, Elsa Rodriguez
Rok vydání: 2015
Předmět:
Zdroj: Organic letters. 17(5)
ISSN: 1523-7052
Popis: A general approach has been developed for the one-pot synthesis of 3,4,5-trisubstituted 1,2,4-triazoles from secondary amides and hydrazides via triflic anhydride activation followed by microwave-induced cyclodehydration. In addition, the 1,2,4-triazole moiety is shown to be a useful directing group for Ru-catalyzed C–H arylation. Access to 1,2,4-triazolophenanthridine can be achieved from the reaction products using a Pd-catalyzed intramolecular C–H functionalization reaction.
Databáze: OpenAIRE