HLA-A29.2 Subtype Associated With Birdshot Retinochoroidopathy
| Autor: | Nezih Ozdemir, Catherine Edelson, J. H. M. Cohen, Renato Semiglia, Alain Benhamou, Hervé Betuel, Phuc LeHoang, Thierry Tabary |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Birdshot retinochoroidopathy Adolescent Genetic Linkage Eye disease Human leukocyte antigen Immunophenotyping Antigen Risk Factors medicine Humans Aged Gel electrophoresis HLA-A Antigens Isoelectric focusing business.industry Histocompatibility Testing Middle Aged medicine.disease Birdshot chorioretinopathy Ophthalmology Chorioretinitis Immunology Electrophoresis Polyacrylamide Gel Female business Retinopathy |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0002-9394 |
| DOI: | 10.1016/s0002-9394(14)75749-6 |
| Popis: | Birdshot retinochoroidopathy is strongly associated with HLA-A29. This antigen can be divided into two subtypes, A29.1 and A29.2, using an immunoprecipitation method succeeded by one-dimensional electrofocusing gel electrophoresis. We reviewed the HLA typings of 58 white French patients who had birdshot retinochoroidopathy. Of these 58 subjects, 54 (93.1%) had HLA-A29 with a relative risk of 157.30. We further analyzed the HLA-A29 subtypings of 33 patients with birdshot retinochoroidopathy. Evaluation of the results showed that HLA-A29.2 subtype was present in all patients (100%). We concluded that the absence of HLA-A29.1 subtype is statistically significant (P less than .01) in this study of HLA-A29 subtyping. |
| Databáze: | OpenAIRE |
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