Clinico-biological features and outcome of patients with splenic marginal zone lymphoma with histological transformation
| Autor: | Bastidas-Mora, Gabriela, Bea, Sílvia, Navarro, Alba, Gine, Eva, Costa, Dolors, Delgado, Julio, Baumann, Tycho, Magnano, Laura, Rivas-Delgado, Alfredo, Villamor, Neus, Colomer, Dolors, Lopez-Guerra, Mónica, Rozman, María, Balagué, Olga, Martínez, Daniel, Baptista, Maria Joao, Escoda, Lourdes, Alcoceba, Miguel, Blanes, Margarita, Climent, Fina, Campo, Elias, Wotherspoon, Andrew, López Guillermo, Armando, Matutes, Estella, Universitat Autònoma de Barcelona |
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| Přispěvatelé: | Instituto de Salud Carlos III, Asociación Española Contra el Cáncer, Generalitat de Catalunya, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), European Commission |
| Rok vydání: | 2022 |
| Předmět: |
Adult
Male medicine.medical_specialty Survival Cèl·lules B medicine.medical_treatment Splenectomy Prognostic factors Gastroenterology Immunophenotyping International Prognostic Index Internal medicine Biomarkers Tumor medicine Humans Cumulative incidence Splenic marginal zone lymphoma Càncer Histological transformation In Situ Hybridization Fluorescence Aged Neoplasm Staging Cancer B cells business.industry Incidence Splenic Neoplasms Complex karyotype Hazard ratio Disease Management Lymphoma B-Cell Marginal Zone Hematology Middle Aged Prognosis medicine.disease BCL6 Immunohistochemistry Lymphoma Cell Transformation Neoplastic B symptoms Cytogenetic Analysis Female Disease Susceptibility Neoplasm Grading medicine.symptom business Spleen |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname Dipòsit Digital de la UB Universidad de Barcelona British Journal of Haematology r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol |
| ISSN: | 2018-0942 1365-2141 |
| Popis: | We describe 36 patients with splenic marginal zone lymphoma (SMZL) with transformation (SMZL-T), including 15 from a series of 84 patients with SMZL diagnosed at the Hospital Clinic of Barcelona (HCB) and 21 diagnosed with SMZL-T in other centres. In the HCB cohort, the cumulative incidence of transformation at 5 years was 15%. Predictors for transformation were cytopenias, hypoalbuminaemia, complex karyotype (CK) and both the Intergruppo Italiano Linfomi (ILL) and simplified Haemoglobin, Platelet count, lactate dehydrogenase (LDH) and extrahilar Lymphadenopathy (HPLL)/ABC scores (P This work was supported by grants from Fondo de Investigaciones Sanitarias, Instituto de Salud Carlos III (PI17/01061 to Sílvia Beà, PI19/00887 to Armando López-Guillermo), Fundacion AECC/CIBERONC (PROYE18020BEA to Sílvia Beà), and CIBERONC (CB16/12/00334 to Dolors Colomer, and CB16/12/00225 to Elías Campo), Generalitat de Catalunya Suport Grups de Recerca AGAUR, 2017-SGR-709 (to Sílvia Beà) 2017-SGR-1009 (to Dolors Colomer), 2017-SGR-1142 (to Elías Campo), Ministerio de Ciencia e Innovación (MCI) [Grant No. RTI2018-094274-B-I00 (to Elías Campo)] and the European Regional Development Fund ‘Una manera de fer Europa’. Elías Campo is an Academia Researcher of the ‘Institució Catalana de Recerca i Estudis Avançats’ (ICREA) of the Generalitat de Catalunya. |
| Databáze: | OpenAIRE |
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