Radiation therapy of spinal metastases: Results with different fractionations
| Autor: | A. Montagna, Zurlo A, C. Pirolli, Mattia Falchetto Osti, Enrici Rm, E. Notarianni, Tombolini |
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| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty etiology/prevention /&/ control Palliative treatment medicine.medical_treatment Pain 030218 nuclear medicine & medical imaging Dose-Response Relationship 03 medical and health sciences 0302 clinical medicine Pain control 80 and over medicine Humans In patient Aged Aged 80 and over Radiation Spinal Neoplasms business.industry Dose-Response Relationship Radiation Radiotherapy Dosage General Medicine Pain scale Adult Aged Aged 80 and over Dose-Response Relationship Radiation Female Humans Male Middle Aged Pain etiology/prevention /&/ control Radiotherapy Dosage Spinal Fractures prevention /&/ control Spinal Neoplasms complications/radiotherapy/secondary Treatment Outcome Middle Aged complications/radiotherapy/secondary Radiation therapy Treatment Outcome Oncology 030220 oncology & carcinogenesis Total dose Spinal Fractures prevention /&/ control Female Radiology Vertebral collapse Spinal metastases business |
| Zdroj: | Scopus-Elsevier |
| Popis: | Aims and background Local radiotherapy plays an important role in the palliative treatment of all skeletal metastases, particularly those of the spine, with the purpose to obtain pain relief and prevent pathologic fractures or vertebral collapse. Methods From June 1991 to October 1993, 95 patients with a total of 103 sites of spinal metastases were treated at the Institute of Radiology of the University of Rome “La Sapienza”. Fractionations and total doses were divided as single fractions of 800 cGy, hypofractionated multiple fractions for a total dose of 20 Gy administered in 4-5 days, and conventional multiple fractions for a total dose of 30-40 Gy in 2-4 weeks. An evaluation of the efficacy of the different radiation treatments was performed with the use of a simplified descriptive pain scale. Results Seventy-three (70.9%) of 103 treatments were evaluables. An overall response rate of 82.2% was obtained: complete in 38.3% and partial in 43.8%, irrespective of total dose, fractionation and location of irradiated spinal metameres. The analysis of results did not show significant differences between the treatment courses. Conclusions We confirm that radiation therapy has a major role in the management of pain control and prevention of fractures in patients with spinal metastases. Hypofractionated and single fraction treatments showed equal efficacy compared to more prolonged therapy, with an advantage for the patient and the radiation therapy institution. |
| Databáze: | OpenAIRE |
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