Restoration of enteroendocrine and pancreatic function after internal hernia and short bowel syndrome in a young woman with gastric bypass:a 2-year follow-up
| Autor: | Jens F. Rehfeld, Bolette Hartmann, Filip K. Knop, Simon Veedfald, Märta Kristina Borghede, Lars Vinter-Jensen, David P. Sonne, Henrik Højgaard Rasmussen, Jens J. Holst |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Short Bowel Syndrome 0301 basic medicine Internal hernia medicine.medical_specialty Hernia Gastric bypass gut hormones Physiology Enteroendocrine Cells medicine.medical_treatment Case Report 030209 endocrinology & metabolism Case Reports short bowel syndrome Anastomosis Gastroenterology Gastrointestinal Hormones Jejunum Young Adult 03 medical and health sciences 0302 clinical medicine RYGB Physiology (medical) Internal medicine Metabolism and Regulation Humans Medicine Pancreas business.industry digestive oral and skin physiology Bowel resection Cephalic phase Postprandial Period Short bowel syndrome medicine.disease 030104 developmental biology Parenteral nutrition medicine.anatomical_structure Gastrointestinal Hepatic and Pancreatic Physiology Duodenum Female Endocrine and Metabolic Conditons Disorders and Treatments business Follow-Up Studies |
| Zdroj: | Borghede, M, Vinter-Jensen, L, Rasmussen, H H, Veedfald, S, Rehfeld, J F, Hartmann, B, Holst, J J, Knop, F K & Sonne, D P 2018, ' Restoration of enteroendocrine and pancreatic function after internal hernia and short bowel syndrome in a young woman with gastric bypass : a 2-year follow-up ', Physiological Reports, vol. 6, no. 9, e13686 . https://doi.org/10.14814/phy2.13686 Borghede, M, Vinter-Jensen, L, Rasmussen, H H, Veedfald, S, Rehfeld, J F, Hartmann, B, Holst, J J, Knop, F K & Sonne, D P 2018, ' Restoration of enteroendocrine and pancreatic function after internal hernia and short bowel syndrome in a young woman with gastric bypass-a 2-year follow-up ', Physiological Reports, vol. 6, no. 9, e13686, pp. 1-6 . https://doi.org/10.14814/phy2.13686 Physiological Reports BASE-Bielefeld Academic Search Engine |
| DOI: | 10.14814/phy2.13686 |
| Popis: | A serious complication to the laparoscopic Roux‐en‐Y gastric bypass (RYGB) is internal hernia, which can lead to massive bowel necrosis that may result in short bowel syndrome. We determined postprandial enteropancreatic hormonal responses and metabolites in a 22‐year‐old nondiabetic woman with a history of RYGB experiencing severe internal herniation with widespread bowel necrosis. Extensive resections were performed leaving her with a saliva fistula from the pouch‐enteric anastomosis, an intact duodenum, 15 cm of jejunum, 35 cm of ileum, and intact colon. Parenteral nutrition was initiated and 10 months after the bowel resection, intestinal continuity was re‐established. After 6 weeks the patient reached parenteral nutrition independence. She underwent standardized liquid mixed meal tests before, 3 months after and 2 years after intestinal continuity was re‐established. Gut hormone responses were completely restored postoperatively leading to very high concentrations in plasma. After 2 years, plasma concentrations had, however, decreased markedly, suggesting desensitization of the gut ostensibly in response to chronic hyperstimulation. There was no evidence of cephalic phase insulin secretion. |
| Databáze: | OpenAIRE |
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