Ecotoxicological assessment of chemotherapeutic agents using toxicity tests with embryos of Mellita quinquiesperforata
| Autor: | Taina Garcia da Fonseca, Abessa Denis Moledode de Souza, Luiza Costa Mello |
|---|---|
| Přispěvatelé: | Universidade Estadual Paulista (Unesp), Universidade do Algarve |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
Chemotherapeutics Environmental Sciences & Ecology Marine & Freshwater Biology Sewage Antineoplastic Agents 010501 environmental sciences Aquatic Science Marine pollution Ecotoxicology Oceanography 01 natural sciences Toxicology Toxicity Tests Animals Ecotoxicity 0105 earth and related environmental sciences EC50 Mellita quinquiesperforata biology business.industry 010604 marine biology & hydrobiology Embryo Biota biology.organism_classification Pollution 3. Good health 13. Climate action Sea Urchins Toxicity Pharmaceuticals business Brazil Water Pollutants Chemical Echinoderms |
| Zdroj: | Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| Popis: | Made available in DSpace on 2020-12-12T01:32:40Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-10-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) The consumption of anticancer agents has increased in the recent decades, and these substances may be present in sewage. Consequently, they may reach the environment when sanitation infrastructure is ineffective. This study evaluated the toxicity of three anticancer agents—Tamoxifen (TAM), Cisplatin (CisPt), and Cyclophosphamide (CP)—on the development of embryos of the sand-dollar Mellita quinquiesperforata. Adult individuals were collected in sandy beaches, and gametes were obtained. Freshly-fertilized eggs were exposed to increasing sets of concentrations of each compound, and the effective concentrations needed to cause a 50% effect in the organisms (EC50) were calculated. The three compounds were toxic, and their EC50 values were 16.78 ± 2.42 ng·L−1 (TAM), 27.20 ± 38.26 ng·L−1 (CisPt), and 101.82 ± 70.96 ng·L−1 (CP). There is no information on the environmental levels of these compounds in Brazil, but as they were already detected in ng·L−1 levels worldwide, it can be expected that these substances pose environmental risks to the marine biota. Center of Studies on Aquatic Pollution and Ecoxicology (NEPEA) São Paulo State University - UNESP Centre for Marine and Environmental Research (CIMA) Universidade do Algarve, Campus de Gambelas Center of Studies on Aquatic Pollution and Ecoxicology (NEPEA) São Paulo State University - UNESP FAPESP: 18/19123-9 CNPq: 202360/2014-8 CNPq: 308533/2018-6 CNPq: 311609/2014-7 |
| Databáze: | OpenAIRE |
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