Correlation between receptor-interacting protein 140 expression and directed differentiation of human embryonic stem cells into neural stem cells
| Autor: | Jingzhu Guo, Huan Shen, Cheng Shi, Qing Mu, Zhuran Zhao, Weidong Yu, Xiao Feng, Xi Chen, Rong Liang, Xue Zhang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cellular differentiation Sox2 Oct4 Biology extracellular regulated kinase 1/2 signaling pathway Stem cell marker lcsh:RC346-429 Nestin 03 medical and health sciences Directed differentiation Developmental Neuroscience SOX2 Neurosphere receptor-interacting protein 140 nerve regeneration neural stem cells human embryonic stem cells directed differentiation neural regeneration lcsh:Neurology. Diseases of the nervous system Embryonic stem cell Neural stem cell 030104 developmental biology Neuroscience Research Article |
| Zdroj: | Neural Regeneration Research, Vol 12, Iss 1, Pp 118-124 (2017) Neural Regeneration Research |
| ISSN: | 1673-5374 |
| Popis: | Overexpression of receptor-interacting protein 140 (RIP140) promotes neuronal differentiation of N2a cells via extracellular regulated kinase 1/2 (ERK1/2) signaling. However, involvement of RIP140 in human neural differentiation remains unclear. We found both RIP140 and ERK1/2 expression increased during neural differentiation of H1 human embryonic stem cells. Moreover, RIP140 negatively correlated with stem cell markers Oct4 and Sox2 during early stages of neural differentiation, and positively correlated with the neural stem cell marker Nestin during later stages. Thus, ERK1/2 signaling may provide the molecular mechanism by which RIP140 takes part in neural differentiation to eventually affect the number of neurons produced. |
| Databáze: | OpenAIRE |
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