Application of green tea catechins, polysaccharides, and flavonol prevent fine dust induced bronchial damage by modulating inflammation and airway cilia
| Autor: | Hyunjung Choi, Dong-Hwa Choi, Hyung-June Kim, Juewon Kim, Kyuhee Park, Miyoung Park |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Cell Survival Science Inflammation Green tea extract Pharmacology medicine.disease_cause Polysaccharide Antioxidants Catechin Article 03 medical and health sciences Nutraceutical Downregulation and upregulation Polysaccharides Ciliogenesis medicine Cilia chemistry.chemical_classification Multidisciplinary Tea 030102 biochemistry & molecular biology Plant Extracts Natural hazards Chemical biology Environmental sciences Oxidative Stress 030104 developmental biology Risk factors chemistry Medicine medicine.symptom Oxidation-Reduction Cosmeceutical Oxidative stress |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021) |
| ISSN: | 2045-2322 |
| Popis: | Airborne fine dust particles (FDPs) have been identified as major toxins in air pollution that threaten human respiratory health. While searching for an anti-FDP reagent, we found that green tea extract (GTE) and fractions rich in flavonol glycosides (FLGs) and crude tea polysaccharides (CTPs) had protective effects against FDP-stimulated cellular damage in the BEAS-2B airway epithelial cell line. The GTE, FLGs, and CTPs significantly increased viability and lowered oxidative stress levels in FDP-treated cells. Combined treatment with GTE, FLGs, and CTPs also exerted synergistic protective effects on cells and attenuated FDP-induced elevations in inflammatory gene expression. Moreover, the green tea components increased the proportion of ciliated cells and upregulated ciliogenesis in the airway in FDP-stimulated BEAS-2B cells. Our findings provide insights into how natural phytochemicals protect the airway and suggest that green tea could be used to reduce FDP-induced airway damage as an ingredient in pharmaceutical, nutraceutical, and also cosmeceutical products. |
| Databáze: | OpenAIRE |
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