DEPRESSION OF DRUG METABOLISM IN THE MOUSE BY A COMBINATION OF Mycobacterium butyricum AND ANAESTHETICS
| Autor: | Edward I. Ciaccio, Edward J. Barbieri |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Male
Pentobarbital Time Factors Inflammation Pharmacology Mixed Function Oxygenases Mycobacterium Subcutaneous injection In vivo medicine Animals Ketamine Depression (differential diagnoses) Anesthetics biology business.industry biology.organism_classification Rats Depression Chemical Anesthesia medicine.symptom Oxidoreductases Sleep business Drug metabolism Research Article medicine.drug |
| Zdroj: | British Journal of Pharmacology. 65:111-115 |
| ISSN: | 0007-1188 |
| DOI: | 10.1111/j.1476-5381.1979.tb17339.x |
| Popis: | 1 Subcutaneous injection of Mycobacterium butyricum suspended in mineral oil into the mouse hind paw caused an oedematous local inflammation. Hind paw swelling was maximum 5 days after injection and was still apparent at day 30. 2 Drug metabolism in vivo (as monitored by ketamine- or pentobarbitone-induced sleeping times) was not affected by the inflammatory disease. However, administration of ketamine or pentobarbitone at day 1 led to significantly elevated sleeping times when the mice showing local inflammation were retested at day 5 with the anaesthetics. 3 Indomethacin inhibited hind paw oedema in the mouse but did not affect ketamine-Mycobacterium butyricum-induced depression of drug metabolism. 4 Prolongation of ketamine-induced anaesthesia by combination with Mycobacterium butyricum at day 5 correlated with the degree of hind paw inflammation at this time. 5 The data suggest that anaesthetics (i.e., ketamine and pentobarbitone) may sensitize hepatic membranes to the effect of Mycobacterium butyricum or some toxic compound elaborated during the active phase of inflammation. |
| Databáze: | OpenAIRE |
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