Treatment of residual metastases with Na[trans-RuCl4 (DMSO)lm] and ruthenium uptake by tumor cells
| Autor: | Enzo Alessio, Moreno Cocchietto, Ilaria Capozzi, Gianni Sava, Alberta Bergamo, Giovanni Mestroni |
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| Rok vydání: | 1996 |
| Předmět: |
Cancer Research
Lung Neoplasms Neoplasm Residual Tumor target Lung metastasis chemistry.chemical_element Tumor cells Antineoplastic Agents Ruthenium Extracellular matrix Mice medicine Organometallic Compounds Animals Pharmacology (medical) Dimethyl Sulfoxide Pharmacology Chemistry Carcinoma Mammary Neoplasms Experimental Long-term potentiation medicine.disease Primary tumor Survival Analysis Oncology Total dose Cancer research |
| Zdroj: | Europe PubMed Central |
| ISSN: | 0959-4973 |
| Popis: | Treatment of MCa mammary carcinoma metastases by i.p. administration of a total dose of 450 mg/kg Na[trans-RuCl4(DMSO)lm], after successful surgical removal of primary tumor mass, causes a significant prolongation of the host's life-time expectancy. This effect, related to lung metastasis inhibition, seems not attributable to a direct inhibition of tumor cells since antimetastatic effects can be achieved also when drug treatment occurs before tumor cell injection into the host. Also, the activity of Na[trans-RuCl4(DMSO)lm] seems independent of its concentration in tumor cells. Rather it must be stressed that the fate of this compound in the blood, following i.v. administration, is fast and only a very low percent of the total dose reaches the tumor target in the lungs. These data emphasize the possibility that Na[trans-RuCl4(DMSO)lm] increases the resistance of the host against metastasis formation, possibly by the already shown mechanism of potentiation of the extracellular matrix and reduction of blood stream invasion by tumor cells. |
| Databáze: | OpenAIRE |
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