Evidence for diagnosis of early chronic pancreatitis after three episodes of acute pancreatitis: a cross-sectional multicentre international study with experimental animal model
| Autor: | Melania Macarie, Dániel Pécsi, Bálint Erőss, Emese Tóth, Alexandra Mikó, Viktória Venglovecz, Péter Mátrai, Zoltán Szepes, Alexandra Soós, Áron Vincze, Ferenc Izbéki, Attila Ébert, József Hamvas, György Kovács, Tanya Bideeva, Ville Sallinen, Balázs Németh, Péter Jenő Hegyi, Péter Hegyi, Márta Varga, László Czakó, Dmitry S. Bordin, Ali Tüzün Ince, Andrea Szentesi, Elena Ramirez-Maldonado, E.A. Dubtsova, Mária Papp, Adrienn Halász, Mariya A. Kiryukova, Judit Bajor, Patrícia Sarlós, Zsolt Dubravcsik, Artautas Mickevicius, Katalin Márta, Igor Khatkov, Andrea Párniczky, László Tiszlavicz |
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| Přispěvatelé: | Clinicum, HUS Abdominal Center, Pertti Panula / Principal Investigator, Department of Anatomy, II kirurgian klinikka, University of Helsinki, Helsinki University Hospital Area, IV kirurgian klinikka, İNCE, ALİ TÜZÜN |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Cross-sectional study Science Population Disease Gastroenterology Article 03 medical and health sciences Mice 0302 clinical medicine Internal medicine Pancreatitis Chronic medicine Animals Humans Registries Risk factor education Pancreatic disease Gastrointestinal diseases education.field_of_study Multidisciplinary business.industry Middle Aged medicine.disease a cross-sectional multicentre international study with experimental animal model.- Scientific reports cilt.11 ss.1367 2021 [Hegyi P. J. Soós A. Tóth E. Ébert A. Venglovecz V. Márta K. Mátrai P. Mikó A. Bajor J. Sarlós P. et al. -Evidence for diagnosis of early chronic pancreatitis after three episodes of acute pancreatitis] 3. Good health Clinical trial Disease Models Animal medicine.anatomical_structure Cross-Sectional Studies Early Diagnosis Pancreatitis 030220 oncology & carcinogenesis 3121 General medicine internal medicine and other clinical medicine Acute pancreatitis Medicine 030211 gastroenterology & hepatology Female Pancreas business |
| Zdroj: | Scientific reports, Heidelberg : Nature research, 2021, vol.11, no. 1, art. no. 1367, p. [1-14] Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021) |
| ISSN: | 2045-2322 |
| Popis: | Chronic pancreatitis (CP) is an end-stage disease with no specific therapy; therefore, an early diagnosis is of crucial importance. In this study, data from 1315 and 318 patients were analysed from acute pancreatitis (AP) and CP registries, respectively. The population from the AP registry was divided into AP (n = 983), recurrent AP (RAP, n = 270) and CP (n = 62) groups. The prevalence of CP in combination with AP, RAP2, RAP3, RAP4 and RAP5 + was 0%, 1%, 16%, 50% and 47%, respectively, suggesting that three or more episodes of AP is a strong risk factor for CP. Laboratory, imaging and clinical biomarkers highlighted that patients with RAP3 + do not show a significant difference between RAPs and CP. Data from CP registries showed 98% of patients had at least one AP and the average number of episodes was four. We mimicked the human RAPs in a mouse model and found that three or more episodes of AP cause early chronic-like morphological changes in the pancreas. We concluded that three or more attacks of AP with no morphological changes to the pancreas could be considered as early CP (ECP).The new diagnostic criteria for ECP allow the majority of CP patients to be diagnosed earlier. They can be used in hospitals with no additional costs in healthcare. |
| Databáze: | OpenAIRE |
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