The effect of cyclic AMP on expression of the major immediate-early genes and replication of human cytomegalovirus in human central nervous system cell lines
| Autor: | J. Tanaka, Rie Yamada, Hidetaka Sadanari, Kuniharu Ohnishi, Keiko Matsubara, Shizuo Fukuda, Tsugiya Murayama |
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| Rok vydání: | 1999 |
| Předmět: |
Human cytomegalovirus
Genes Viral Cytomegalovirus Astrocytoma Biology Virus Replication medicine.disease_cause Herpesviridae Cell Line Immediate-Early Proteins Neuroblastoma Virology Glioma Gene expression Cyclic AMP Tumor Cells Cultured medicine Humans Enhancer Genes Immediate-Early Lung Brain Neoplasms General Medicine medicine.disease Kinetics Bucladesine Cell culture Immediate early gene |
| Zdroj: | Archives of Virology. 144:1015-1025 |
| ISSN: | 1432-8798 0304-8608 |
| DOI: | 10.1007/s007050050564 |
| Popis: | The effect of dibutyryl cyclic AMP (dbcAMP) on interaction of human cytomegalovirus (HCMV) with human central nervous system cell lines was examined. Activation of the major immediate-early (IE) promoter (MIEP) of HCMV by dbcAMP was observed in human neuroblastoma IMR-32 cells, but not in glioma 118MGC and astrocytoma U373-MG cells. The 19 bp repeat element in the enhancer of the MIEP was most likely to be the cis-element that responded to dbcAMP in IMR-32 cells as we expected. In IMR-32 cells activation of the MIEP led to enhanced synthesis of the major IE proteins and infectious HCMV. |
| Databáze: | OpenAIRE |
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