Changes in macular drusen parameters preceding the development of neovascular age-related macular degeneration
| Autor: | Sobha Sivaprasad, Adam M. Dubis, Ali Lamin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Time Factors genetic structures Fundus Oculi Retinal Drusen Drusen Article Age related Ophthalmology medicine Humans Macula Lutea Fluorescein Angiography Aged Retrospective Studies medicine.diagnostic_test business.industry Retrospective cohort study Macular degeneration Fluorescein angiography medicine.disease Prognosis Occult eye diseases Disease Progression Wet Macular Degeneration Macular drusen Female Electronic database sense organs business Tomography Optical Coherence Follow-Up Studies |
| Zdroj: | Eye (Lond) |
| Popis: | PURPOSE: To assess the rate of change in macular drusen load in fellow eyes of patients with unilateral neovascular age-related macular degeneration (AMD) to evaluate whether the change in drusen load determines the onset and type of choroidal neovascularisation (CNV). METHODS: Subjects with unilateral neovascular AMD with a minimum of 2 years follow-up were identified retrospectively from the hospital electronic database. Drusen count, area and volume measurements at the macula of the contralateral eye were recorded using the commercial software on the Topcon 3D OCT-2000 devices over the previous 2 years. The mean rate of change of these parameters over time was compared between fellow eyes that converted to various CNV subtypes and those that did not. RESULTS: Two hundred forty-eight patients met the inclusion criteria. Of these patients, 179 patients did not progress to neovascular AMD (Group 1) while 69 patients converted (Group 2) at the end of 2 years follow up. Mean drusen volumes and drusen areas increased significantly in Group 2 in the 2nd year by 0.031 mm(3) (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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