Sesquiterpenes from Thapsia nitida var. meridionalis and Thapsia nitida var. nitida
| Autor: | Karla Frydenvang, F. Javier Moreno-Dorado, S. Brøgger Christensen, Ulla Wagner Smitt, Margit Eriksson, Guillermo M. Massanet, Juan J. Rubal, Zacarías D. Jorge, Helmer Søhoel, Francisco M. Guerra, Charlotte Nielsen |
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| Rok vydání: | 2006 |
| Předmět: |
Molecular Conformation
Pharmaceutical Science Pharmacognosy Crystallography X-Ray Sesquiterpene Plant Roots Sarcoplasmic Reticulum Calcium-Transporting ATPases Analytical Chemistry chemistry.chemical_compound Drug Discovery Botany Spectral analysis Medicinal plants Thapsia Pharmacology Plants Medicinal Apiaceae Molecular Structure biology Organic Chemistry biology.organism_classification Terpenoid Thapsia (plant) Complementary and alternative medicine chemistry Spain Chemotaxonomy Molecular Medicine Sesquiterpenes |
| Zdroj: | Journal of Natural Products. 69:1566-1571 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np0603065 |
| Popis: | Nine new eudesmanolides (1-9), two new guaianolides (12 and 13), and a new germacrane (10), along with a previously reported guaianolide (11), have been isolated from the roots of Thapsia nitida var. meridionalis. Thapsia nitida var. nitida also afforded compound 13 along with a new guaianolide (14). The structure of 13 was confirmed by X-ray crystallographic analysis. Compounds 1, 2, and 11-14 have been tested as potential inhibitors of the sarco- and endoplasmic Ca2+-dependent ATPases (SERCA) pump. None of them showed significant activities. |
| Databáze: | OpenAIRE |
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