Isolation of resveratrol from peanut sprouts, radioiodination and investigation of its bioactivity on neuroblastoma cell lines
| Autor: | Kadriye Busra Karatay, Fazilet Zumrut Biber Muftuler, Emin Ilker Medine, Ayfer Yurt Kilcar, Ozge Kozgus Guldu |
|---|---|
| Přispěvatelé: | Ege Üniversitesi |
| Rok vydání: | 2020 |
| Předmět: |
Peanut sprouts
Antioxidant Health Toxicology and Mutagenesis medicine.medical_treatment Human neuroblastoma cell lines Public Health Environmental and Occupational Health Treatment options Pharmacology Resveratrol Radioiodination Pollution Analytical Chemistry Bioavailability Neuroblastoma cell chemistry.chemical_compound Nuclear Energy and Engineering chemistry Cell culture medicine Radiology Nuclear Medicine and imaging Iodine-131 Spectroscopy |
| Zdroj: | Journal of Radioanalytical and Nuclear Chemistry. 325:75-84 |
| ISSN: | 1588-2780 0236-5731 |
| Popis: | Recently, natural antioxidant substances have been purified in a significant increasing incline from different plants for diagnosis and treatment options. in the current study, Resveratrol (RES) was isolated and radioiodinated with iodine-131 ([I-131]iodo-RES). Cell culture studies were conducted on neuroblastoma cells (SY-SH5Y and SK-N-AS) to investigate the bioavailability of [I-131]iodo-RES. the radioiodination yield of RES was 98.81 +/- 0.37% (n = 6). Uptake values up to 25% were observed notably on SK-N-AS cells until 24 h. Briefly; the current study will contribute to the development of novel radiolabeled plant origin agents for the imaging of neuroblastoma cells. Ege University Scientific Research ProjectsEge University; Ege University/TURKEYEge University [FYL-2018-20081] Present study was supported by Ege University Scientific Research Projects, Ege University/TURKEY (Project Number: FYL-2018-20081). Authors thank to Mr. Resat YILDIZ for sending the seeds from "Osmaniye Oil Seeds Research Institute", Osmaniye/TURKEY. Also, authors thank to Dr. Volkan TEKIN and Msc. Cansu KAYAS for their technical help and thank to Mr. Ali Rza GULMEZ for support in growing peanut sprouts. |
| Databáze: | OpenAIRE |
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