Presence of epoxide hydrolase and glutathione S-transferase in human pulmonary alveolar macrophages
| Autor: | Anders Rane, Paolo Paoletti, G. M. Pacifici, P. Bernard, Carlo Giuntini, Stefano Petruzzelli |
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| Rok vydání: | 1988 |
| Předmět: |
Male
chemistry.chemical_compound stomatognathic system parasitic diseases medicine Humans Macrophage Pharmacology (medical) Epoxide hydrolase Glutathione Transferase Epoxide Hydrolases Pharmacology chemistry.chemical_classification Bronchus biology medicine.diagnostic_test Chemistry Macrophages General Medicine Glutathione Middle Aged respiratory system Molecular biology Pulmonary Alveoli Glutathione S-transferase medicine.anatomical_structure Enzyme Bronchoalveolar lavage Biochemistry embryonic structures biology.protein Female Pulmonary alveolus |
| Zdroj: | European Journal of Clinical Pharmacology. 34:419-421 |
| ISSN: | 1432-1041 0031-6970 |
| Popis: | Pulmonary alveolar macrophages (PAMs) were obtained from 11 patients by bronchoalveolar lavage. Epoxide hydrolase and glutathione S-transferase in sonicated PAMs were measured using benzo(a)pyrene-4,5-oxide as the substrate. The activity of epoxide hydrolase was 0.24 +/- 0.10 nmol/min/mg protein (mean +/- SD), and of glutathione S-transferase 0.22 +/- 0.12 nmol/min/mg protein. There was a significant difference in enzyme activities in the PAMs from smokers and non-smokers. Epoxides may be metabolized in PAMs. |
| Databáze: | OpenAIRE |
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