Gene-Expressing Liposomes as Synthetic Cells for Molecular Communication Studies
| Autor: | Francesca D'Angelo, Pasquale Stano, Giordano Rampioni, Livia Leoni |
|---|---|
| Přispěvatelé: | Rampioni, Giordano, D'Angelo, Francesca, Leoni, Livia, Stano, Pasquale, Rampioni, G., D'Angelo, F., Leoni, L., Stano, P. |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Histology Computer science lipid vesicles (liposomes) Mini Review lcsh:Biotechnology Cell Biomedical Engineering Bioengineering 02 engineering and technology Computational biology 03 medical and health sciences Synthetic biology lcsh:TP248.13-248.65 Gene expression medicine molecular communications Gene Liposome Cell-free protein synthesis Molecular communication business.industry Bottom-up synthetic biology Cell-free protein synthesis Lipid vesicles (liposomes) Molecular communications Quorum sensing Synthetic cells Biotechnology Bioengineering Biomedical Engineering Bioengineering and Biotechnology quorum sensing synthetic cells Modular design 021001 nanoscience & nanotechnology cell-free protein synthesis 030104 developmental biology medicine.anatomical_structure bottom-up synthetic biology 0210 nano-technology business Biotechnology |
| Zdroj: | Frontiers in Bioengineering and Biotechnology, Vol 7 (2019) Frontiers in Bioengineering and Biotechnology |
| ISSN: | 2296-4185 |
| DOI: | 10.3389/fbioe.2019.00001/full |
| Popis: | The bottom-up branch of synthetic biology includes—among others—innovative studies that combine cell-free protein synthesis with liposome technology to generate cell-like systems of minimal complexity, often referred to as synthetic cells. The functions of this type of synthetic cell derive from gene expression, hence they can be programmed in a modular, progressive and customizable manner by means of ad hoc designed genetic circuits. This experimental scenario is rapidly expanding and synthetic cell research already counts numerous successes. Here, we present a review focused on the exchange of chemical signals between liposome-based synthetic cells (operating by gene expression) and biological cells, as well as between two populations of synthetic cells. The review includes a short presentation of the “molecular communication technologies,” briefly discussing their promises and challenges. |
| Databáze: | OpenAIRE |
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