Immune Regulation in T1D and T2D: Prospective Role of Foxp3+ Treg Cells in Disease Pathogenesis and Treatment
| Autor: | Ciriaco A. Piccirillo, Mara Kornete, Edward S. Mason |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
obesity
Endocrinology Diabetes and Metabolism Autoimmunity Inflammation Review Article Type 2 diabetes medicine.disease_cause lcsh:Diseases of the endocrine glands. Clinical endocrinology Immune tolerance 03 medical and health sciences Endocrinology 0302 clinical medicine Immune system Insulin resistance metabolic Immune Tolerance medicine 030304 developmental biology 0303 health sciences Type 1 diabetes lcsh:RC648-665 diabetes business.industry immune regulation FOXP3 medicine.disease 3. Good health Treg Diabetes Mellitus Type 1 Diabetes Mellitus Type 2 inflammation Foxp3 Immunology medicine.symptom business 030215 immunology |
| Zdroj: | Frontiers in Endocrinology Frontiers in Endocrinology, Vol 4 (2013) |
| ISSN: | 1664-2392 |
| DOI: | 10.3389/fendo.2013.00076 |
| Popis: | There is increasing evidence that dysregulated immune responses play key roles in the pathogenesis and complications of type 1 but also type 2 diabetes. Indeed, chronic inflammation and autoimmunity, which are salient features of type 1 diabetes, are now believed to actively contribute to the pathogenesis of type 2 diabetes. The accumulation of activated innate and adaptive immune cells in various metabolic tissues results in the release of inflammatory mediators, which promote insulin resistance and β-cell damage. Moreover, these dysregulated immune responses can also mutually influence the prevalence of both type 1 and 2 diabetes. In this review article, we discuss the central role of immune responses in the patho-physiology and complications of type 1 and 2 diabetes, and provide evidence that regulation of these responses, particularly through the action of regulatory T cells, may be a possible therapeutic avenue for the treatment of these disease and their respective complications. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|