Helicobacter Pylori Infection in Texas Hispanic and Non-Hispanic White Men: Implications for Gastric Cancer Risk Disparities
| Autor: | Robin J. Leach, Amelie G. Ramirez, Dorothy Long Parma, Susan M. Ogden, Edgar Munoz, Gustavo Figueiredo Marcondes Westin, Ian M. Thompson |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
men of color
Male medicine.medical_specialty Health (social science) health inequality/disparity Adenocarcinoma White People Helicobacter Infections 03 medical and health sciences 0302 clinical medicine Risk Factors Stomach Neoplasms medicine Prevalence Humans Obesity Family history Risk factor Aged Gynecology Cancer prevention biology cancer prevention Helicobacter pylori business.industry Public Health Environmental and Occupational Health Cancer Health Status Disparities Hispanic or Latino Middle Aged biology.organism_classification medicine.disease Texas 3. Good health 030220 oncology & carcinogenesis Relative risk Cohort 030211 gastroenterology & hepatology Racial and Ethnic Diversity and Disparity Issues business Demography quantitative research |
| Zdroj: | American Journal of Men's Health |
| ISSN: | 1557-9891 1557-9883 |
| Popis: | Chronic Helicobacter pylori ( H. pylori) infection is a major gastric adenocarcinoma (GA) risk factor. GA disproportionately affects U.S. Hispanics compared with non-Hispanic Whites (NHWs). Since H. pylori infection studies in Hispanics are few, infection rates in Hispanic and NHW men in Bexar County were compared, and relationships with ethnicity and obesity examined. Age- and zip code-matched participants from a community-dwelling cohort were randomly selected. Sera from 284 men were analyzed by enzyme immunoassay for H. pylori antibodies. Adjusted risk ratio estimation for matched data was conducted to identify differences. Hispanics had a markedly higher prevalence of infection (30.3%) than NHWs (9.2%). Matched risk ratio (mRR) analyses revealed a strong association between H. pylori seropositivity and Hispanic ethnicity (mRR = 3.31; 95% CI [1.91, 5.73], adjusted by BMI, smoking status, and family history of cancer (mRR range = 3.28-3.89). BMI mRRs (range = 1.19-1.22) were significant in all models. In this cohort, Hispanic men had higher H. pylori infection rates than NHWs, and parallel the disproportionately higher rates of GA; obesity contributes to this higher prevalence. Future studies should address country of origin, acculturation, and other factors influencing obesity to further elucidate risk of GA in Hispanic populations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|