Regulation of gene expression associated with acute experimental autoimmune encephalomyelitis by Lovastatin
| Autor: | Avtar K. Singh, Manjeet K. Paintlia, Anne G. Gilg, Ernest Barbosa, Romesh Stanislaus, Ajaib S. Paintlia, Inderjit Singh |
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| Rok vydání: | 2004 |
| Předmět: |
Chemokine
Encephalomyelitis Autoimmune Experimental Multiple Sclerosis Microarray Genes MHC Class II Peroxisome proliferator-activated receptor Biology Severity of Illness Index Cellular and Molecular Neuroscience medicine Animals Lovastatin RNA Messenger Growth Substances Receptor Transcription factor Oligonucleotide Array Sequence Analysis chemistry.chemical_classification Regulation of gene expression Microarray analysis techniques Experimental autoimmune encephalomyelitis medicine.disease Rats Up-Regulation Disease Models Animal Gene Expression Regulation Spinal Cord chemistry Rats Inbred Lew Immunology biology.protein Cytokines Female Hydroxymethylglutaryl-CoA Reductase Inhibitors Transcription Factors |
| Zdroj: | Journal of Neuroscience Research. 77:63-81 |
| ISSN: | 1097-4547 0360-4012 |
| Popis: | The attenuation of experimental autoimmune encephalomyelitis (EAE) by Lovastatin (LOV) has now been well established. The present study was designed to explore the global effect of LOV treatment on expression of immune-related genes in lumbar spinal cord (LSC) during acute EAE by using Affymetrix DNA microarrays. LOV treatment demonstrated the limited infiltration of inflammatory cells into the LSC, and microarray analysis further validated those interpretations by demonstrating relatively less alteration in expression of immune response genes in LOV-treated EAE rats on peak clinical day and recovery vs. untreated EAE counterparts. There was significant change in expression of about 158 immune-related genes (including 127 genes reported earlier) in LOV-treated vs. untreated EAE (>1.5 or |
| Databáze: | OpenAIRE |
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