Questioning the utility of round spermatid injections in men with non-obstructive azoospermia
| Autor: | Roy Mano, Snir Dekalo, Ofer Yossepowitch, Foad Azem, Shimi Barda, Ofer Lehavi, Sandra E. Kleiman, Ron Hauser |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Sperm Retrieval Y chromosome microdeletion Urology Endocrinology Diabetes and Metabolism Physical examination Spermatocyte 03 medical and health sciences 0302 clinical medicine Endocrinology Medicine Humans reproductive and urinary physiology Azoospermia Retrospective Studies Gynecology 030219 obstetrics & reproductive medicine Spermatid medicine.diagnostic_test urogenital system business.industry Sertoli cell medicine.disease Spermatids Testicular sperm extraction medicine.anatomical_structure Reproductive Medicine Histopathology business |
| Zdroj: | AndrologyREFERENCES. 9(4) |
| ISSN: | 2047-2927 |
| Popis: | Background Data on who among the infertile male population may benefit from round spermatid injections (ROSI) are lacking. Objective To determine the probability of finding round spermatids suitable for ROSI in men with non-obstructive azoospermia (NOA) in whom no spermatozoa were retrieved at testicular sperm extraction. Materials and methods Four-hundred fifty-seven consecutive men with azoospermia underwent testicular sperm extraction. Clinical examination included age, secondary sexual characteristics, testicular size, reproductive hormone estimation, karyotyping, and Y chromosome microdeletion analyses. Histologic examination was performed, and histologic classification was determined by the most advanced spermatogenetic cell identified in the combined histologic and cytologic examination. Results Of the 457 azoospermic men, 342 were diagnosed with NOA, and 148 (148/342, 43%) had mixed atrophy on histopathology and retrievable spermatozoa. No spermatozoa were found in 194/342 men with NOA (57%). Histopathology diagnosed 145/194 (75%) of them with Sertoli cell only, 45/194 (23%) with spermatocyte maturation arrest, and 4/194 (2%) with spermatid maturation arrest. Conclusions Histopathologically identified round spermatids without spermatozoa were rare in men with NOA. Only very few of them are likely to reap the benefits of ROSI, thus presenting the need to reconsider its actual clinical value. |
| Databáze: | OpenAIRE |
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