Bovine herpes virus type 4 alters TNF-α and IL-8 profiles and impairs the survival of bovine endometrial epithelial cells
| Autor: | Jean-Francois Valarcher, Renée Båge, Gunilla Blomqvist, Mikael Juremalm, Karin Ullman, Patrice Humblot, M. Chanrot, Yongzhi Guo, Gaetano Donofrio |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_treatment Semen Biology In vitro model Andrology Endometrium 03 medical and health sciences Endocrinology Multiplicity of infection Herpes virus medicine Animals Interleukin 8 Cells Cultured Cell survival Tumor Necrosis Factor-alpha Transmission (medicine) Interleukin-8 Epithelial Cells Herpesvirus 4 Bovine 030104 developmental biology Cytokine Immunology Cattle Female Animal Science and Zoology Transcriptome Developmental Biology |
| Zdroj: | Reproductive Biology. 17:225-232 |
| ISSN: | 1642-431X |
| DOI: | 10.1016/j.repbio.2017.05.006 |
| Popis: | Bovine herpes virus type 4 (BoHV-4) can be transmitted by contaminated semen to cows at the time of breeding and may cause uterine disease. The aim of this study was to characterize the susceptibility of bovine endometrial epithelial cells (bEEC) to BoHV-4 by using an in vitro model. When bEEC were challenged with different multiplicity of infection (MOI; from 0.001 to 10) of BoHV-4 for 6days, a significant decrease in cell survival with increasing MOI was observed. The bEEC were subsequently challenged with BoHV-4 MOI 0.1 for 7days. During the first 4days, numbers increased in a similar way in controls and infected group (p |
| Databáze: | OpenAIRE |
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