Kinetic studies and production rate of equine (e) FSH in ovariectomized pony mares. Application to the determination of a dosage regimen for eFSH in a superovulation treatment
| Autor: | T Magallon, M. Ottogalli, Christine Briant, P.-L. Toutain, D. Guillaume |
|---|---|
| Přispěvatelé: | Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Physiopathologie et Toxicologie Expérimentales (UPTE), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2004 |
| Předmět: |
endocrine system
medicine.medical_specialty Ovariectomy [SDV]Life Sciences [q-bio] Endocrinology Diabetes and Metabolism Superovulation Breeding 03 medical and health sciences 0302 clinical medicine Endocrinology Ovulation Induction Latin square Internal medicine biology.animal FSH medicine Seasonal breeder Animals HORMONE GONADOTROPE [INFO]Computer Science [cs] Horses ComputingMilieux_MISCELLANEOUS Plasma clearance 030219 obstetrics & reproductive medicine Daily production Dose-Response Relationship Drug biology Pony business.industry 0402 animal and dairy science 04 agricultural and veterinary sciences 040201 dairy & animal science Regimen Ovariectomized rat Female E-FSH Follicle Stimulating Hormone business Production rate |
| Zdroj: | Journal of Endocrinology Journal of Endocrinology, BioScientifica, 2004, 182, pp.43-54 |
| ISSN: | 1479-6805 0022-0795 |
| DOI: | 10.1677/joe.0.1820043 |
| Popis: | The appropriate dosage regimen for equine FSH (eFSH) (dose, dosing interval) administration in a superovulation treatment in pony mares was determined by a kinetic approach using production rates and kinetic parameters of elimination of the hormone. Two dosage regimens were then tested in superovulation protocols. The eFSH production rates were determined by sampling four ovariectomized pony mares every 10 min for 8 h during the breeding season. Kinetic parameters were determined by administering four dose levels of a preparation of eFSH (4.4, 8.8, 17.6 and 35.2 micro g/kg) by the i.v. route to the same mares, in a randomized 4x4 Latin Square protocol. The overall mean plasma clearance was 0.256+/- 0.07 ml.kg(-1).min(-1), and was independent of the dose. The mean residence time ranged from 5.5 to 10.8 h and increased with the dose. The estimated FSH production rates were 8.6 to 15.3 micro g.kg(-1).day(-1) (i.e. 2.89 to 3.45 mg per day per mare). Two dosage regimens of eFSH were then tested in cyclic mares (ten treated mares in each trial): 3.45 mg per day (4.4 micro g/kg three times a day by the i.v. route), which corresponds to the maximal daily production rate of the native hormone in ovariectomized mares, and 1.72 mg per day (2.2 micro g/kg three times a day), which corresponds to half of that production rate. The dosage regimen of 2.2 micro g/kg three times a day gave satisfactory results in terms of efficacy (numbers of ovulations and embryos) with minimal unwanted effects (luteinized or anovulatory follicles). |
| Databáze: | OpenAIRE |
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