An Adipose Tissue Atlas: An Image-Guided Identification of Human-like BAT and Beige Depots in Rodents
| Autor: | Qiwei Zhai, Yi Zhu, Philipp E. Scherer, Christine M. Kusminski, Qiong A. Wang, Rana K. Gupta, Fang Zhang, Yu An, Xiankai Sun, Kien Nham, Mengle Shao, Guiyang Hao, Orhan K. Öz, Gedaa Hassan |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Pathology medicine.medical_specialty Adolescent Lipodystrophy Physiology Adipose Tissue White Adipose tissue Biology Article 03 medical and health sciences Imaging Three-Dimensional 0302 clinical medicine Adipose Tissue Brown Fluorodeoxyglucose F18 Positron Emission Tomography Computed Tomography Brown adipose tissue Adipocytes medicine Animals Humans Molecular Biology Fluorodeoxyglucose chemistry.chemical_classification PET-CT Iodobenzenes Fatty Acids Fatty acid Thermogenesis Cell Biology Adipose Tissue Beige Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure Gene Expression Regulation chemistry Ct imaging Metabolic activity Biomarkers 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Cell Metabolism. 27:252-262.e3 |
| ISSN: | 1550-4131 |
| Popis: | [18F]Fluorodeoxyglucose-PET/CT (18F-FDG-PET/CT) imaging has been invaluable for visualizing metabolically active adipose tissues in humans with potential anti-diabetic and anti-obesity effects. To explore whether mice display human-like fat depots in anatomically comparable regions, we mapped fat depots using glucose or fatty acid imaging tracers, such as 18F-FDG through PET/CT or [123/125I]-β-methyl-p-iodophenyl-pentadecanoic acid with SPECT/CT imaging, to analogous depots in mice. Using this type of image analysis with both probes, we define a large number of additional areas of high metabolic activity corresponding to novel fat pads. Histological and gene expression analyses validate these regions as bona fide fat pads. Our findings indicate that fat depots of rodents show a high degree of topological similarity to those of humans. Studies involving both glucose and lipid tracers indicate differential preferences for these substrates in different depots and also suggest that fatty acid-based visualized approaches may reveal additional brown adipose tissue and beige depots in humans. |
| Databáze: | OpenAIRE |
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