Effect of hyperglycemia on gastric acid secretion and gastrin release induced by intravenous amino acids
| Autor: | Ad A.M. Masclee, E. S. M. Muller, C. B. H. W. Lamers, W. F. Lam |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Medicine (miscellaneous) Pancreatic Polypeptide Gastric Acid Internal medicine Gastrins medicine Pancreatic polypeptide Humans Secretion Amino Acids Infusions Intravenous Gastrin chemistry.chemical_classification Nutrition and Dietetics business.industry Stomach Amino acid medicine.anatomical_structure Endocrinology Glucose Gastrointestinal hormone chemistry Gastric Mucosa Hyperglycemia Gastric acid Liberation Female business |
| Zdroj: | The American journal of clinical nutrition. 61(6) |
| ISSN: | 0002-9165 |
| Popis: | Intravenous amino acids (IVAAs) are able to stimulate gastric acid secretion. We investigated the effect of concomitant intravenous infusion of glucose, leading to hypergly- cemia, on gastric acid secretion induced by IVAAs. Seven healthy volunteers were studied twice, once during normoglycemia and once during acute hyperglycemia with blood glucose concentra- tions stabilized at � 15 mmol/L. Amino acids were infused intra- venously at the rate of 10 g/h for 180 mm. Acid output was measured by continuous aspiration using a recovery marker. Se- rum gastrin and plasma pancreatic polypeptide (PP) concentrations were determined at regular intervals. IVAAs significantly stimu- lated acid output compared with basal values (2.3 ± 0.2 and 1.4 ± 0.4 mmol/15 mm, respectively, P < 0.05), release of gastrin, and PP during normoglycemia. Hyperglycemia completely inhibited (P < 0.05) IVAA-induced gastric acid output and significantly inhibited (P < 0.05) release of gastrin and PP. We conclude that IVAAs stimulate gastric acid secretion, and gastrin and PP release; acute hyperglycemia reduces IVAA-stimulated acid output, and gastrin and PP release; and circulating nutrients influence gastric acid and gastrointestinal hormone secretion. Am J C/in Nutr 1995;61 :1268-72. |
| Databáze: | OpenAIRE |
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