Association of the −344T/C polymorphism in aldosterone synthase gene promoter with left ventricular structure in Chinese Han: A meta-analysis
Autor: | Wei Gu, Shaojun Wen, Xuanzu Chen, Chengqian Yin, Yun Gao, Zhao Li, Zhi-Zhong Li |
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Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Aldosterone synthase medicine.medical_specialty Physiology Heart Ventricles Diastole Blood Pressure 030204 cardiovascular system & hematology Biology Left ventricular hypertrophy Polymorphism Single Nucleotide 03 medical and health sciences 0302 clinical medicine Asian People Polymorphism (computer science) Internal medicine Genotype Internal Medicine medicine Cytochrome P-450 CYP11B2 Humans cardiovascular diseases Promoter Regions Genetic Homozygote Organ Size General Medicine Publication bias medicine.disease Phenotype 030104 developmental biology Blood pressure Meta-analysis biology.protein Cardiology Hypertrophy Left Ventricular |
Zdroj: | Clinical and Experimental Hypertension. 39:562-569 |
ISSN: | 1525-6006 1064-1963 |
Popis: | No consensus view has been published on the relationship between the aldosterone synthase gene (CYP11B2) -344C/T polymorphism and left ventricular hypertrophy (LVH) in Chinese Han. We undertook a meta-analysis to investigate the potential association of this polymorphism and left ventricular structure-related phenotypes, including left ventricular mass (LVM), left ventricular mass index (LVMI), left ventricular end systolic diameter (LVESD), left ventricular end diastolic dimension (LVEDD), left ventricular posterior wall thickness (LVPWT), and interventricular septal wall thickness (IVS). Studies in English and Chinese were found based on a systematic search of Medline, Embase, CNKI, and Wanfang databases. The dominant model (TT vs. TC+CC) and homozygote model (TT vs. CC) were selected to examine the association between the -344C/T polymorphism and LVH. The random-effects model was used to pool data. From a total of 3104 participants, despite the investigation of six echocardiographic indicators, we found no significant association between the -344C/T variant and LVH in the whole group and the subgroup analyses by blood pressure. However, in the subgroup of northern Han Chinese, TT genotype had higher LVPWT than CC genotype and TC genotype (pheterogeneity = 0.4, pvalue = 0.04, 95% CI 0.09 (0.00, 0.18)). In addition, no evidence of publication bias was observed. In conclusion, our meta-analysis indicated that subjects with TT genotype might have higher risk of developing LVH in northern Han Chinese. |
Databáze: | OpenAIRE |
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