Electrospinning scale-up and formulation development of PVA nanofibers aiming oral delivery of biopharmaceuticals
| Autor: | Zs. Petho, Tamás Vigh, Geert Verreck, Enikő Bitay, Balázs Démuth, Panna Vass, Zs. Nagy, Sune K. Andersen, Edit Hirsch, Kolos Molnár, Gy. Marosi |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Materials science
Polymers and Plastics Electrospinning General Chemical Engineering Scale-up Organic Chemistry Oral formulation Nanotechnology lcsh:Chemical technology Biopharmaceuticals Nanofiber SCALE-UP Materials Chemistry lcsh:TA401-492 lcsh:Materials of engineering and construction. Mechanics of materials lcsh:TP1-1185 Physical and Theoretical Chemistry Nanomaterials |
| Zdroj: | eXPRESS Polymer Letters, Vol 13, Iss 7, Pp 590-603 (2019) |
| Popis: | Electrospinning is a promising drying technology providing a rapid and gentle drying at ambient temperature, thus electrospinning of polyvinyl alcohol aqueous solutions was investigated for the solid formulation of biopharmaceuticals. The commonly used single-needle electrospinning does not have adequate productivity to satisfy the industrial requirements, therefore our aim was to study the scale-up of the technology by using high-speed electrospinning. High molecular weight polyethylene oxide as a secondary polymer was applied to enhance the fiber formation of polyvinyl alcohol. While polyvinyl alcohol-polyethylene oxide formulations resulted in adequate fiber formation it was not possible to process them further as the friability of the fibers was too low. In order to increase the friability, the effect of adding various sugars (mannitol, glucose, lactose, saccharose, and trehalose) was investigated. The results showed that mannitol was the best friability enhancing excipient because of its crystallinity and low moisture content in the fibrous sample. In contrast, glucose, lactose, saccharose, and trehalose were amorphous with higher moisture content and fibers containing these were grindable only after post-drying. |
| Databáze: | OpenAIRE |
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