Landiolol hydrochloride for prevention of atrial fibrillation during esophagectomy: a randomized controlled trial
| Autor: | Kazuki Ide, Yohei Kawasaki, Junichiro Yokoyama, Yuichiro Shimizu, Yoshitaka Aoki, Shinsuke Sato |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment 030204 cardiovascular system & hematology Landiolol hydrochloride Placebo law.invention lcsh:RD78.3-87.3 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Anesthesiology medicine 030212 general & internal medicine Intraoperative complications Clinical Research Article business.industry lcsh:Medical emergencies. Critical care. Intensive care. First aid lcsh:RC86-88.9 Perioperative Landiolol Atrial fibrillation Intensive care unit Cardiac surgery Esophagectomy Anesthesiology and Pain Medicine lcsh:Anesthesiology Anesthesia business medicine.drug |
| Zdroj: | JA Clinical Reports JA Clinical Reports, Vol 6, Iss 1, Pp 1-9 (2020) |
| ISSN: | 2363-9024 |
| DOI: | 10.1186/s40981-020-00338-3 |
| Popis: | Introduction Landiolol hydrochloride reduces the incidence of perioperative atrial fibrillation (AF) in cardiac surgery; however, little evidence is available regarding its effects in other types of surgery, including esophagectomy. We assessed the hypothesis that landiolol reduces perioperative AF and other complications associated with esophagectomy. Methods This single-center, randomized, double-blind, parallel-group study enrolled patients scheduled for esophagectomy. Patients were divided into those given landiolol at 3 μg/kg/min or placebo for 24 h. The primary outcome was the proportion of patients who developed AF within 96 h starting at 9:00 am on the day of surgery. The secondary outcomes were the proportion of patients whose AF appeared within 24 h, other complications based on the Clavien–Dindo classification, and the intensive care unit and hospital stays. Results Despite early study termination, 80 patients were screened, and 56 were enrolled (28/group) from September 2016 to June 2018. AF occurred within 96 h of surgery in six (21.4%) patients in the landiolol group and five (17.9%) patients in the placebo group (odds ratio, 1.26; 95% confidence interval, 0.33–4.7) and within 24 h of surgery in three (10.7%) patients in the landiolol group and two (7.1%) patients in the placebo group. There were no significant differences in the incidence of complications or in the number of intensive care unit or hospital stays between the groups. Conclusion Although our small sample size prevents definitive conclusions, landiolol might not reduce the occurrence of AF or other complications. Trial registration UMIN, UMIN000024040. Registered 13 September 2016, http://www.umin.ac.jp/ctr/index/htm |
| Databáze: | OpenAIRE |
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