Comparison of lipid and non-lipid markers of atherosclerosis in arterial versus venous blood
| Autor: | Catherine J. McNeal, Mark W. Riggs, Bruce Palmer, Clinton E. Baisden, Mark E. Lawrence, Ronald D. Macfarlane, Linley E. Watson |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Amyloid
medicine.medical_specialty Apolipoprotein B Arteriosclerosis Clinical Biochemistry Left heart catheterization Veins chemistry.chemical_compound Internal medicine medicine Humans Triglycerides Apolipoproteins B Apolipoprotein A-I biology Triglyceride Vascular disease Cholesterol business.industry Arteries General Medicine Venous blood medicine.disease Lipids Lipoproteins LDL C-Reactive Protein Endocrinology chemistry biology.protein Arterial blood lipids (amino acids peptides and proteins) Lipoproteins HDL business Biomarkers Lipoprotein |
| Zdroj: | Annals of Clinical Biochemistry: International Journal of Laboratory Medicine. 40:286-288 |
| ISSN: | 1758-1001 0004-5632 |
| DOI: | 10.1258/000456303321610637 |
| Popis: | Background: Early studies have suggested that there may be differences in the concentration of lipoprotein particles and their associated apolipoproteins in arterial and venous blood and that this gradient might explain a proclivity to develop atherosclerotic lesions. The aim of this study was to use current methods of analysis to determine levels of these components, including particle densities and several common inflammatory markers in arterial and venous blood. Methods: Samples of arterial and venous blood were obtained nearly simultaneously in 26 patients undergoing right and left heart catheterization. Analyses were performed using enzymatic, immunoturbidimetric and ultracentrifugation assays. Results: Data obtained for total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol, HDL and LDL particle density, high sensitivity C-reactive protein, serum amyloid-A and apoprotein B-100 concentrations in arterial and venous blood did not demonstrate any significant difference in the means. Conclusion: Arterial and venous blood can be used interchangeably to study the effect of blood concentrations of common soluble surrogate markers of atherosclerosis. |
| Databáze: | OpenAIRE |
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