Antimicrobial resistance in Escherichia coli outpatient urinary isolates from women: emerging multidrug resistance phenotypes
| Autor: | Pak-Leung, Ho, River C W, Wong, King-Sun, Yip, Shee-Loong, Loke, Marianne S T, Leung, Gannon C, Mak, Frankie K H, Chow, Kenneth W T, Tsang, Tak-Lun, Que |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Microbiology (medical) Adolescent medicine.drug_class Antibiotics Microbial Sensitivity Tests Biology Fosfomycin beta-Lactamases Microbiology Antibiotic resistance Drug Resistance Multiple Bacterial Ampicillin Outpatients Escherichia coli medicine Humans Escherichia coli Infections Aged General Medicine Middle Aged biochemical phenomena metabolism and nutrition Antimicrobial Anti-Bacterial Agents Multiple drug resistance Ciprofloxacin Phenotype Infectious Diseases Nitrofurantoin Population Surveillance Urinary Tract Infections Hong Kong Female medicine.drug |
| Zdroj: | Diagnostic Microbiology and Infectious Disease. 59:439-445 |
| ISSN: | 0732-8893 |
| DOI: | 10.1016/j.diagmicrobio.2007.06.012 |
| Popis: | This study evaluated the antimicrobial resistance profile of outpatient urinary Escherichia coli isolated from women obtained throughout Hong Kong during 2004–2005. Of 1067 single patient isolates analyzed, 60.1% were resistant to ampicillin, 34% were resistant to co-trimoxazole, and 22.1% were resistant to ciprofloxacin. Thirty-four (6.6%) of 519 isolates in 2004 and 55 (10%) of 548 isolates in 2005 were extended-spectrum β-lactamase (ESBL) producers with a CTX-M phenotype. Rates of non–β-lactam resistance and ESBL production were strongly influenced by patient age. The age-stratified rates for dual co-trimoxazole and ciprofloxacin resistance and for ESBL production were 10.9% and 7.6% in women aged 18–35 years, 13% and 6.9% in women aged 36–50 years, 20.4% and 8.8% in women aged 51–64 years, and 23.7% and 11.8% in women aged ≥65 years, respectively. Nitrofurantoin and fosfomycin remain active against >90% of the isolates, irrespective of the resistance phenotypes for other drugs. Our results documented the emergence of problematic resistance phenotypes among community urinary E. coli and highlight the need to explore strategies for their containment. |
| Databáze: | OpenAIRE |
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