High-Sensitivity Cardiac Troponin T and Cognitive Function in Patients With Ischemic Stroke
| Autor: | Jan F. Scheitz, Sophie K. Piper, Regina von Rennenberg, Thomas G. Liman, Christian H. Nolte, Bob Siegerink, Peter U. Heuschmann, Pia S. Sperber, Matthias Endres, Leonie H.A. Broersen |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male blood [Troponin T] medicine.medical_specialty epidemiology [Cognitive Dysfunction] physiopathology [Cognitive Dysfunction] Young Adult Cognition Troponin T Interquartile range Internal medicine Odds Ratio Prevalence Medicine Dementia Humans Cognitive Dysfunction ddc:610 Prospective cohort study Stroke Aged Advanced and Specialized Nursing Aged 80 and over physiopathology [Stroke] business.industry Middle Aged medicine.disease Mental Status and Dementia Tests Prognosis blood [Stroke] Telephone interview Quartile blood [Cognitive Dysfunction] Relative risk Linear Models Female Neurology (clinical) psychology [Cognitive Dysfunction] Cardiology and Cardiovascular Medicine business psychology [Stroke] Follow-Up Studies |
| Zdroj: | Stroke 51(5), 1604-1607 (2020). doi:10.1161/STROKEAHA.119.028410 |
| Popis: | Background and Purpose— Our study aim was to assess whether high-sensitivity cardiac troponin T (hs-cTnT), a specific biomarker for myocardial injury, is associated with cognitive function in patients after mild-to-moderate first-ever ischemic stroke. Methods— We used data from PROSCIS-B (Prospective Cohort With Incident Stroke Berlin). Cognitive function was assessed by Mini-Mental-State-Examination at baseline, and Telephone Interview for Cognitive Status–modified after 1 to 3 years of follow-up. Patients were categorized according to hs-cTnT quartiles. We performed generalized linear regression to calculate risk ratios of cognitive impairment (Mini-Mental-State-Examination Results— We included 555 patients (mean age, 67 years, 62% male, median National Institutes of Health Stroke Scale 2 [interquartile range, 1–5], hs-cTnT above upper reference limit 40%, baseline cognitive impairment 28%). Baseline Mini-Mental-State-Examination score and rate of cognitive impairment were lower in patients in the highest versus lowest hs-cTnT quartile (median Mini-Mental-State-Examination 27 versus 29, and 15.3% versus 43.0%, adjusted risk ratio, 1.76 [95% CI, 1.07–2.90], respectively). If anything, cognition seemed to improve in all groups, yet Telephone Interview for Cognitive Status–modified scores were consistently lower in patients within the highest versus lowest hs-cTnT quartile (adjusted β, −1.33 [95% CI, −2.65 to −0.02]), without difference in the rate of change over time. Conclusions— In patients with mild-to-moderate first-ever ischemic stroke without dementia, higher hs-cTnT was associated with higher prevalence of cognitive impairment at baseline and lower Telephone Interview for Cognitive Status–modified during 3-year follow-up. Registration— URL: https://www.clinicaltrials.gov ; Unique identifier: NCT01363856. |
| Databáze: | OpenAIRE |
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