CR Cistrome: a ChIP-Seq database for chromatin regulators and histone modification linkages in human and mouse
| Autor: | Yong Zhang, Jinyan Huang, Qian Qin, Juan Wang, Hanfei Sun, Shenglin Mei, Xiaoqin Yang, X. Shirley Liu, Qian Wang, Qixuan Wang, Chengchen Zhao, Liu Jing |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Chromatin Immunoprecipitation
computer.software_genre Genome II. Protein sequence and structure motifs and domains Histones 03 medical and health sciences Mice 0302 clinical medicine Databases Genetic Genetics Animals Humans natural sciences Epigenetics Transcription factor 030304 developmental biology Histone Demethylases 0303 health sciences Internet Database biology DNA replication Sequence Analysis DNA Chromatin Histone Cistrome 030220 oncology & carcinogenesis biology.protein computer Chromatin immunoprecipitation Transcription Factors |
| Zdroj: | Nucleic Acids Research |
| ISSN: | 1362-4962 0305-1048 |
| Popis: | Diversified histone modifications (HMs) are essential epigenetic features. They play important roles in fundamental biological processes including transcription, DNA repair and DNA replication. Chromatin regulators (CRs), which are indispensable in epigenetics, can mediate HMs to adjust chromatin structures and functions. With the development of ChIP-Seq technology, there is an opportunity to study CR and HM profiles at the whole-genome scale. However, no specific resource for the integration of CR ChIP-Seq data or CR-HM ChIP-Seq linkage pairs is currently available. Therefore, we constructed the CR Cistrome database, available online at http://compbio.tongji.edu.cn/cr and http://cistrome.org/cr/, to further elucidate CR functions and CR-HM linkages. Within this database, we collected all publicly available ChIP-Seq data on CRs in human and mouse and categorized the data into four cohorts: the reader, writer, eraser and remodeler cohorts, together with curated introductions and ChIP-Seq data analysis results. For the HM readers, writers and erasers, we provided further ChIP-Seq analysis data for the targeted HMs and schematized the relationships between them. We believe CR Cistrome is a valuable resource for the epigenetics community. |
| Databáze: | OpenAIRE |
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