The placebo effect on resting tremor in Parkinson's disease: an electrophysiological study
| Autor: | Antonio Augimeri, Maria Giovanna Bianco, Maurizio Morelli, Salvatore Nigro, Marianna Crasà, Giuseppe Nicoletti, Fabiana Novellino, Rita Nisticò, Basilio Vescio, Gennarina Arabia, Gaetano Barbagallo, Aldo Quattrone, Maria Salsone, Andrea Quattrone, Antonio Cerasa, Giuseppe Olivadese |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Parkinson's disease Apomorphine Placebo Statistics Nonparametric 03 medical and health sciences Subcutaneous injection Basal (phylogenetics) 0302 clinical medicine Imaging Three-Dimensional Accelerometry Tremor medicine Humans Resting tremor Placebo effectResting tremorParkinson's diseaseAccelerometerApomorphine Aged medicine.diagnostic_test business.industry Dopaminergic Magnetic resonance imaging Parkinson Disease Middle Aged medicine.disease Placebo Effect Magnetic Resonance Imaging nervous system diseases 030104 developmental biology Treatment Outcome Neurology Anesthesia Dopamine Agonists Female Neurology (clinical) Geriatrics and Gerontology business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Parkinsonism & related disorders 52 (2018): 17–23. doi:10.1016/j.parkreldis.2018.03.012 info:cnr-pdr/source/autori:Gaetano Barbagallo a1 Rita Nisticò b1 Basilio Vescio c Antonio Cerasa b,d, Giuseppe Olivadese b, Salvatore Nigro b, Marianna Crasà b, Andrea Quattrone a, Maria Giovanna Bianco b, Maurizio Morelli a, Antonio Augimeri c, Maria Salsone b, Fabiana Novellino b, Giuseppe Nicoletti b, Gennarina Arabia a, Aldo Quattrone b,e/titolo:The placebo effect on resting tremor in Parkinson's disease: an electrophysiological study./doi:10.1016%2Fj.parkreldis.2018.03.012/rivista:Parkinsonism & related disorders/anno:2018/pagina_da:17/pagina_a:23/intervallo_pagine:17–23/volume:52 |
| ISSN: | 1873-5126 |
| DOI: | 10.1016/j.parkreldis.2018.03.012 |
| Popis: | Introduction The aim of our study was to investigate the effect of apomorphine and placebo on resting tremor in tremor-dominant Parkinson's disease (tPD) patients. Methods Fifteen tPD patients were enrolled. Each patient underwent two treatments on two consecutive days: on day one the patients received a subcutaneous injection of placebo, while on day two they received apomorphine. On each day, the patients underwent three electrophysiological recording sessions: T0, T1, and T2: before, 30 min, and 60 min after the treatment respectively. Electrophysiological changes in tremor amplitude were evaluated using a triaxial accelerometer. Results Placebo was effective in improving resting tremor in all tPD patients (p = 0.009) at T1, but not at T2. Eight out of 15 tPD patients (53.3%) responded to placebo with an at least 70% reduction in tremor amplitude compared to the basal condition (responders). By contrast, seven out of 15 tPD patients (46.7%) did not show any variation in tremor amplitude after placebo administration (non-responders). Apomorphine induced a marked reduction in tremor amplitude at 30 min and 60 min in all investigated tPD patients. Of note, the decrease in tremor amplitude in placebo responders was similar to that achieved with dopaminergic stimulation induced by apomorphine. Conclusions Our study demonstrates that placebo was very effective in reducing resting tremor in about half of patients with tPD. The decrease in tremor amplitude in placebo responders was similar to that induced by apomorphine. The cerebral mechanisms underlying the placebo effect on resting tremor need further investigations. |
| Databáze: | OpenAIRE |
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