Autophagy in cardiomyopathies
| Autor: | Saskia Schlossarek, Antonia T.L. Zech, Sonia R. Singh, Lucie Carrier |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Autophagosome Cardiomyopathy Cellular homeostasis 030204 cardiovascular system & hematology Biology 03 medical and health sciences 0302 clinical medicine Lysosome Organelle Autophagy medicine Homeostasis Humans Molecular Biology Cell Biology medicine.disease Cell biology 030104 developmental biology medicine.anatomical_structure Proteolysis Cardiomyopathies Energy Metabolism Lysosomes Function (biology) |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1867:118432 |
| ISSN: | 0167-4889 |
| DOI: | 10.1016/j.bbamcr.2019.01.013 |
| Popis: | Autophagy (greek auto: self; phagein: eating) is a highly conserved process within eukaryotes that degrades long-lived proteins and organelles within lysosomes. Its accurate and constant operation in basal conditions ensures cellular homeostasis by degrading damaged cellular components and thereby acting not only as a quality control but as well as an energy supplier. An increasing body of evidence indicates a major role of autophagy in the regulation of cardiac homeostasis and function. In this review, we describe the different forms of mammalian autophagy, their regulations and monitoring with a specific emphasis on the heart. Furthermore, we address the role of autophagy in several forms of cardiomyopathy and the options for therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect