NTCP model validation method for DAHANCA patient selection of protons versus photons in head and neck cancer radiotherapy
| Autor: | Maria Andersen, Jeppe Friborg, Kenneth Jensen, Claus Kristensen, Jesper Grau Eriksen, Jørgen Johansen, Jens Overgaard, L. Johnsen, Christian Rønn Hansen, Ruta Zukauskaite, E. Samsøe, Cai Grau, Hanne Primdahl, C. Maare, Åse Bratland |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Organs at Risk
medicine.medical_treatment Denmark Logistic regression TOXICITY 030218 nuclear medicine & medical imaging law.invention Model validation COMPLICATION PROBABILITY-MODELS 0302 clinical medicine Randomized controlled trial law Prevalence Proton Therapy Prospective Studies Radiotherapy Dosage Hematology General Medicine Chemoradiotherapy LEARNING HEALTH-CARE EORTC DAHANCA Oncology Head and Neck Neoplasms 030220 oncology & carcinogenesis RECURRENCES TRIAL Radiology medicine.medical_specialty Antibodies Monoclonal Humanized Models Biological Risk Assessment 03 medical and health sciences medicine Humans Radiology Nuclear Medicine and imaging IMRT Radiation Injuries Selection (genetic algorithm) ZALUTUMUMAB Probability Retrospective Studies Photons business.industry Squamous Cell Carcinoma of Head and Neck Patient Selection Head and neck cancer Retrospective cohort study ONCOLOGY medicine.disease Radiation therapy Radiotherapy Intensity-Modulated business Deglutition Disorders |
| Zdroj: | Hansen, C R, Friborg, J, Jensen, K, Samsøe, E, Johnsen, L, Zukauskaite, R, Grau, C, Maare, C, Johansen, J, Primdahl, H, Bratland, Å, Kristensen, C A, Andersen, M, Eriksen, J G, Overgaard, J & On Behalf of the DAHANCA Group 2019, ' NTCP model validation method for DAHANCA patient selection of protons versus photons in head and neck cancer radiotherapy ', Acta Oncologica, vol. 58, no. 10, pp. 1410-1415 . https://doi.org/10.1080/0284186X.2019.1654129 Hansen, C R, Friborg, J, Jensen, K, Samsøe, E, Johnsen, L, Zukauskaite, R, Grau, C, Maare, C, Johansen, J, Primdahl, H, Bratland, Kristensen, C A, Andersen, M, Eriksen, J G, Overgaard, J & On Behalf of the DAHANCA Group 2019, ' NTCP model validation method for DAHANCA patient selection of protons versus photons in head and neck cancer radiotherapy ', Acta Oncologica, vol. 58, no. 10, pp. 1410-1415 . https://doi.org/10.1080/0284186X.2019.1654129 Hansen, C R, Friborg, J, Jensen, K, Samsøe, E, Johnsen, L, Zukauskaite, R, Grau, C, Maare, C, Johansen, J, Primdahl, H, Bratland, Kristensen, C A, Andersen, M, Eriksen, J G & Overgaard, J 2019, ' NTCP model validation method for DAHANCA patient selection of protons versus photons in head and neck cancer radiotherapy ', Acta Oncologica, vol. 58, no. 10, pp. 1410-1415 . https://doi.org/10.1080/0284186X.2019.1654129 |
| DOI: | 10.1080/0284186X.2019.1654129 |
| Popis: | Introduction: Prediction models using logistic regression may perform poorly in external patient cohorts. However, there is a need to standardize and validate models for clinical use. The purpose of this project was to describe a method for validation of external NTCP models used for patient selection in the randomized trial of protons versus photons in head and neck cancer radiotherapy, DAHANCA 35. Material and methods: Organs at risk of 588 patients treated primarily with IMRT in the randomized controlled DAHANCA19 trial were retrospectively contoured according to recent international recommendations. Dose metrics were extracted using MatLab and all clinical parameters were retrieved from the DAHANCA database. The model proposed by Christianen et al. to predict physician-rated dysphagia was validated through the closed testing, where change of the model intercept, slope and individual beta’s were tested for significant prediction improvements. Results: Six months prevalence of dysphagia in the validation cohort was 33%. The closed testing procedure for physician-rated dysphagia showed that the Christianen et al. model needed an intercept refitting for the best match for the Danish patients. The intercept update increased the risk of dysphagia for the validation cohort by 7.9 ± 2.5% point. For the raw model performance, the Brier score (mean squared residual) was 0.467, which improved significantly with a new intercept to 0.415. Conclusions: The previously published Dutch dysphagia model needed an intercept update to match the Danish patient cohort. The implementation of a closed testing procedure on the current validation cohort allows quick and efficient validation of external NTCP models for patient selection in the future. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|