Survival in Frontotemporal Dementia Phenotypes: A Meta-Analysis
| Autor: | Kelly L. Sloane, Peter V. Rabins, John McGready, Kalyani Kansal, Chiadi U. Onyike, Manisha Mareddy, Alexa A. Minc |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Oncology medicine.medical_specialty Cognitive Neuroscience Semantic dementia Progressive non-fluent aphasia Progressive supranuclear palsy 03 medical and health sciences 0302 clinical medicine Alzheimer Disease Internal medicine mental disorders medicine Humans Corticobasal degeneration Primary Progressive Nonfluent Aphasia 030212 general & internal medicine Aged business.industry Amyotrophic Lateral Sclerosis nutritional and metabolic diseases medicine.disease Phenotype nervous system diseases Survival Rate Psychiatry and Mental health Frontotemporal Dementia Meta-analysis Mixed effects Female Supranuclear Palsy Progressive Geriatrics and Gerontology business Neuroscience 030217 neurology & neurosurgery Frontotemporal dementia |
| Zdroj: | Dementia and Geriatric Cognitive Disorders. 41:109-122 |
| ISSN: | 1421-9824 1420-8008 |
| DOI: | 10.1159/000443205 |
| Popis: | Background: Survival in frontotemporal dementia (FTD) is not well understood. We conducted a mixed effects meta-analysis of survival in FTD to examine phenotype differences and contributory factors. Methods: The PubMed, Medline, EMBASE, CINAHL, PsycINFO and Cochrane databases were searched for studies describing survival or natural history of behavioral variant FTD (bvFTD), progressive non-fluent aphasia (PNFA), semantic dementia (SD), FTD with amyotrophic lateral sclerosis (FTD-ALS), progressive supranuclear palsy and corticobasal degeneration. There were no language restrictions. Results: We included 27 studies (2,462 subjects). Aggregate mean and median survival were derived for each phenotype and, for comparison, Alzheimer's disease (AD) (using data from the selected studies). Survival was shortest in FTD-ALS (2.5 years). Mean survival was longest in bvFTD and PNFA (8 years) and median survival in SD (12 years). AD was comparable in survival to all except FTD-ALS. Age and sex did not affect survival; the education effect was equivocal. Heterogeneity in FTD survival was largely, but not wholly, explained by phenotypes. Conclusions: Survival differs for FTD phenotypes but, except for FTD-ALS, compares well to AD survival. Elucidating the potential causes of within-phenotype heterogeneity in survival (such as complicating features and comorbidities) may open up opportunities for tailored interventions. |
| Databáze: | OpenAIRE |
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