Linking objective measures of physical activity and capability with brain structure in healthy community dwelling older adults

Autor: Lars T. Westlye, Geneviève Richard, Kristine Moe Ulrichsen, Anne-Marthe Sanders, Erlend S. Dørum, Knut K. Kolskår, Dag Alnæs, Jan Egil Nordvik, Ann-Marie Glasø de Lange, Tobias Kaufmann, Dani Beck
Rok vydání: 2021
Předmět:
Male
MRI
Magnetic resonance imaging
BMI
body mass index
Hippocampus
Grip strength
FA
fractional anisotropy
TBSS
Tract-Based Spatial Statistics
Brain
Regular Article
White Matter
Diffusion Tensor Imaging
medicine.anatomical_structure
Neurology
Female
Independent Living
MRI
M-V steps/day
moderate- to vigorous intensity steps per day
medicine.medical_specialty
Cognitive Neuroscience
Computer applications to medicine. Medical informatics
R858-859.7
TFCE
threshold-free cluster enhancement
DTI
Diffusion tensor imaging
Neuroimaging
ICV
intracranial volume
White matter
Physical medicine and rehabilitation
ROI
regions of interest
Physical capability
Fractional anisotropy
medicine
Humans
Radiology
Nuclear Medicine and imaging
RC346-429
Exercise
Aged
MD
mean diffusivity
Physical activity
business.industry
Public health
Brain morphometry
BAG
brain age gap
10 MWT
Timed 10-Meter Walk Test
Preferred walking speed
Cross-Sectional Studies
Brain aging
Anisotropy
Neurology. Diseases of the nervous system
Neurology (clinical)
business
Diffusion MRI
Zdroj: NeuroImage : Clinical
NeuroImage: Clinical, Vol 31, Iss, Pp 102767-(2021)
ISSN: 2213-1582
DOI: 10.1016/j.nicl.2021.102767
Popis: Highlights • Examining associations between physical activity, physical capability and brain health. • Higher global FA were observed in older adults with higher walking speed. • Lower subcortical brain age gap (BAG) were observed in more physically active women.
Maintaining high levels of daily activity and physical capability have been proposed as important constituents to promote healthy brain and cognitive aging. Studies investigating the associations between brain health and physical activity in late life have, however, mainly been based on self-reported data or measures designed for clinical populations. In the current study, we examined cross-sectional associations between physical activity, recorded by an ankle-positioned accelerometer for seven days, physical capability (grip strength, postural control, and walking speed), and neuroimaging based surrogate markers of brain health in 122 healthy older adults aged 65–88 years. We used a multimodal brain imaging approach offering complementary structural MRI based indicators of brain health: global white matter fractional anisotropy (FA) and mean diffusivity (MD) based on diffusion tensor imaging, and subcortical and global brain age based on brain morphology inferred from T1-weighted MRI data. In addition, based on the results from the main analysis, follow-up regression analysis was performed to test for association between the volume of key subcortical regions of interest (hippocampus, caudate, thalamus and cerebellum) and daily steps, and a follow-up voxelwise analysis to test for associations between walking speed and FA across the white matter Tract-Based Spatial Statistics (TBSS) skeleton. The analyses revealed a significant association between global FA and walking speed, indicating higher white matter integrity in people with higher pace. Voxelwise analysis supported widespread significant associations. We also found a significant interaction between sex and subcortical brain age on number of daily steps, indicating younger-appearing brains in more physically active women, with no significant associations among men. These results provide insight into the intricate associations between different measures of brain and physical health in old age, and corroborate established public health advice promoting physical activity.
Databáze: OpenAIRE
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