Platelet prostanoid receptors
| Autor: | Roma A. Armstrong |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Blood Platelets
medicine.medical_specialty Thromboxane Receptors Prostaglandin Receptors Thromboxane Prostacyclin Receptors Epoprostenol Thromboxane receptor chemistry.chemical_compound Internal medicine medicine Humans Receptors Prostaglandin E Pharmacology (medical) Platelet Platelet activation Receptors Immunologic Receptor Pharmacology Chemistry Prostanoid Endocrinology Thromboxanes lipids (amino acids peptides and proteins) Signal Transduction medicine.drug |
| Zdroj: | Pharmacology & Therapeutics. 72:171-191 |
| ISSN: | 0163-7258 |
| DOI: | 10.1016/s0163-7258(96)00103-9 |
| Popis: | Prostaglandins (PGs) and thromboxanes are important modulators of platelet activation, and there is strong evidence to support the existence of distinct thromboxane, prostacyclin, PGD 2 and PGE 2 receptors on the platelet plasma membrane. In this review, each of these platelet prostanoid receptors is discussed in detail, with respect to their receptor pharmacology, molecular biology and signal transduction, and as to any therapeutic implications of the development of specific agonists and/or antagonists. In addition, it considers the possibility that there are separate vascular receptors for 8-epi PGF 2α , which are not present on the platelet. |
| Databáze: | OpenAIRE |
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