Inhibitory activities of microalgal extracts against Epstein-Barr Virus (EBV) antigen expression in lymphoblastoid cells
| Autor: | Wan-Loy Chu, Yih Yih Koh, Alan Soo Beng Khoo, Shar Mariam Mohamed, Joon Wah Mak, Siew-Moi Phang, P. K. C. Lim, Balraj Pauline, Pey Jiun Lai, Shui Nyuk Ling, Naidu Rakesh |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Activator (genetics)
Lymphoblast microalgae Immunocytochemistry Synechococcus elongatus Biology medicine.disease medicine.disease_cause Epstein–Barr virus General Biochemistry Genetics and Molecular Biology Lymphoma Microbiology Epstein-Barr virus (EBV) Membrane protein Antigen lcsh:Biology (General) Cell culture hemic and lymphatic diseases medicine Ankistrodesmus convolutes General Agricultural and Biological Sciences lcsh:QH301-705.5 |
| Zdroj: | Archives of Biological Sciences, Vol 66, Iss 3, Pp 1009-1024 (2014) |
| ISSN: | 1821-4339 0354-4664 |
| Popis: | The inhibitory activities of microalgal extracts against the expression of three EBV antigens, latent membrane protein (LMP)1, Epstein-Barr nuclear antigen (EBNA)1 and Z Epstein-Barr reactivation activator (ZEBRA) were assessed by immunocytochemistry. The observation that the methanol extracts and their fractions from Ankistrodesmus convolutus, Synechococcus elongatus and Spirulina platensis exhibited inhibitory activity against EBV proteins in three Burkitt?s lymphoma cell lines at concentrations as low as 20 ?g/ml suggests that microalgae could be a potential source of antiviral compounds against EBV. |
| Databáze: | OpenAIRE |
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