CONDITION OF ANTI-MEASLES IMMUNITY IN PATIENTS ON WAITING-LIST FOR LUNG TRANSPLANTATION
| Autor: | D. A. Blagovidov, Ryzhov Aa, G. V. Vasileva, I. V. Vlukachev, V. B. Polischuk, A. D. Shmitko, O O Magarshak, Kostinov Mp, N. A. Karchevskaya, A. G. Chuchalin, S. N. Avdeev |
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| Jazyk: | ruština |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Medicine (miscellaneous) Disease 030230 surgery Measles Gastroenterology Microbiology Measles virus 03 medical and health sciences 0302 clinical medicine Immunity Internal medicine medicine lung transplantation Lung transplantation measles 030212 general & internal medicine vaccine-controlled infections immune-competent patients biology business.industry General Medicine medicine.disease biology.organism_classification Confidence interval QR1-502 Vaccination anti-measles antibodies biology.protein Antibody business |
| Zdroj: | Журнал микробиологии, эпидемиологии и иммунобиологии, Vol 0, Iss 4, Pp 55-60 (2016) |
| ISSN: | 2686-7613 0372-9311 |
| Popis: | Aim. Determination of intensity of immunity against measles in patients on waiting-list for lung transplantation. Materials and methods. IgG levels against measles virus were studied in blood sera of 80 adult patients (mean age 35.8± 11.4 years) on waiting-list of lung transplantation, without history of this disease. Determination of IgG levels against measles virus was carried out by ELISA using a standard kit from «Vektor-Best» (VectoMeasles-IgG). Results. Protective level of IgG against measles virus (above 0.18 I U/ml) was registered in 83.3% of examined patients. Mean level of anti-measles antibodies was within protective values - 1.53 IU/ml (95% confidence interval 1.17 - 1.89). Medium level of anti-measles antibodies (1 - 5 IU/ml) was registered in most of the analyzed samples (55.2%). A positive correlation between values of antibodies and age of patients (r=0.43) was detected. Dependence between levels of antibodies and previously executed hormonal and cytostatic therapy was not detected. Conclusion. Patients on waiting-list of solid organ transplantation are a group of risk for development of severe course of measles infection, that dictates the necessity of execution of vaccination at short terms before or after registration on the waiting-list. |
| Databáze: | OpenAIRE |
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