Pulmonary effects of sulfur dioxide and respirable carbon aerosol
| Autor: | Thomas J. Kulle, Larry R. Sauder, J. R. Hebel, F. Shanty, Donald J. Green, W.R. Miller |
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| Rok vydání: | 1986 |
| Předmět: |
Adult
Male Pulmonary effects chemistry.chemical_element Mineralogy Biochemistry chemistry.chemical_compound Animal science medicine Humans Sulfur Dioxide Respiratory system Lung Sulfur dioxide General Environmental Science Aerosols Throat irritation Inhalation Eye irritation Carbon Aerosol chemistry Irritants Female medicine.symptom |
| Zdroj: | Environmental research. 41(1) |
| ISSN: | 0013-9351 |
| Popis: | Four-hour individual and combined exposures to 1.0 ppm sulfur dioxide (SO/sub 2/) and 0.5 mg/m/sup 3/ (1.5 ..mu..m mass median diameter) activated carbon aerosol (ACA) were studied in 20 healthy nonsmoking subjects to determine if activated carbon as a carrier aerosol can augment the pulmonary response to SO/sub 2/. Fifteen-minute exercise stints (V/sub E/ = 35 liters/min) were performed at commencement and completion of each 4-hr period. Significant increases in nose or throat irritation occurred with the SO/sub 2/ and SO/sub 2/ + ACA exposures and in eye irritation with the SO/sub 2/ + ACA exposure. Small, statistically significant decrements in spirometric function were observed following the first exercise (t = 17 min) for both the SO/sub 2/ and SO/sub 2/ plus ACA exposures: no significant changes were associated with the ACA exposure. Comparing function changes between the SO/sub 2/ and the SO/sub 2/ + ACA exposures demonstrated no statistically significant differences, thus a lack of SO/sub 2/ response enhancement by the carbon aerosol. The determination that the activated carbon sorbed only 1% of the SO/sub 2/ challenge concentration could explain the observed lack of SO/sub 2/ response enhancement. |
| Databáze: | OpenAIRE |
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