Cerebral Small Vessel Disease Associated with Subclinical Vascular Damage Indicators in Asymptomatic Hypertensive Patients
| Autor: | Paula Andrea Arias-Cadena, Sergio González-García, Melany Betancourt-Loza, Anay Cordero-Eiriz, Marta Brown-Martínez, Marisol Peña-Sánchez, Zenaida Hernández-Díaz, Alina González-Quevedo Monteagudo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
lcsh:BF1-990 030204 cardiovascular system & hematology Development Asymptomatic Article 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Hypertensive retinopathy Internal medicine Genetics medicine Dementia risk factors cardiovascular diseases Stroke General Psychology Ecology Evolution Behavior and Systematics Subclinical infection business.industry cerebral small vessel disease brain lesions essential hypertension white matter hyperintensities medicine.disease Hyperintensity lcsh:Psychology Cardiology Microalbuminuria medicine.symptom business 030217 neurology & neurosurgery Retinopathy |
| Zdroj: | Behavioral Sciences Behavioral Sciences, Vol 9, Iss 9, p 91 (2019) Volume 9 Issue 9 |
| ISSN: | 2076-328X |
| Popis: | Background: Cerebral small vessel disease (CSVD) is frequent in patients with cardiovascular risk factors including arterial hypertension, and it is associated with vascular damage in other organs and the risk of stroke, cognitive impairment, and dementia. Early diagnosis of CSVD could prevent deleterious consequences. Objective: To characterize CSVD associated with indicators of subclinical vascular damage in asymptomatic hypertensive patients. Materials and Methods: Participants were hypertensive (HT) and non-hypertensive (non-HT) individuals without signs of cerebrovascular disease, dementia, and chronic renal failure. For CSVD, white matter hyperintensities (WMH), enlarged Virchow&ndash Robin perivascular spaces (EVRPS), lacunar infarcts, and microbleeds were investigated. Subclinical vascular damage was evaluated (hypertensive retinopathy, microalbuminuria, and extracranial carotid morphology: intima media thickness (IMT) and atheroma plaque). Results: CSVD MRI findings were more frequent in HT as well as greater intimal thickening. The IMT + plaque was significantly associated with all MRI variables but retinopathy was correlated with EVRPS and lacunar infarcts. Only microalbuminuria was related to the greater severity of WMH in HT. Multivariate analysis evidenced that CSVD was independently associated with the combination of indicators of vascular damage and systolic blood pressure. Conclusions: Combining indicators of subclinical vascular damage, such as carotid morphological variables, microalbuminuria, and hypertensive retinopathy for early detection of CSVD in asymptomatic hypertensive patients could prove to be useful to take actions for the prevention of irreversible brain damage, which could lead to cognitive impairment, dementia and stroke. |
| Databáze: | OpenAIRE |
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