Multimodal Investigation of Neuroinflammation in Aviremic Patients With HIV on Antiretroviral Therapy and HIV Elite Controllers
| Autor: | Hasan, Sari, Riccardo, Galbusera, Guillaume, Bonnier, Yang, Lin, Zeynab, Alshelh, Angel, Torrado-Carvajal, Shibani S, Mukerji, Eva M, Ratai, Rajesh T, Gandhi, Jacqueline T, Chu, Oluwaseun, Akeju, Vwaire, Orhurhu, Andrew N, Salvatore, Janet, Sherman, Douglas S, Kwon, Bruce, Walker, Bruce, Rosen, Julie C, Price, Lauren E, Pollak, Marco, Loggia, Cristina, Granziera |
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| Rok vydání: | 2022 |
| Předmět: |
Male
Brain Diseases Correction & Replacement HIV Infections Neuroimaging Middle Aged Magnetic Resonance Imaging Multimodal Imaging Neurology Anti-Retroviral Agents Positron-Emission Tomography Neuroinflammatory Diseases HIV Non-Progressors Humans Cognitive Dysfunction Female Neurology (clinical) Aged |
| Zdroj: | Neurol Neuroimmunol Neuroinflamm |
| ISSN: | 2332-7812 |
| Popis: | The presence of HIV in the CNS has been related to chronic immune activation and cognitive dysfunction. The aim of this work was to investigate (1) the presence of neuroinflammation in aviremic people with HIV (PWH) on therapy and in nontreated aviremic PWH (elite controllers [ECs]) using a translocator protein 18 kDa radioligand; (2) the relationship between neuroinflammation and cognitive function in aviremic PWH; and (3) the relationship between [[In region of interest analyses, ECs exhibited significantly lower [This study casts a new light onto the role of neuroinflammation and related microstructural alterations of HIV infection in the CNS and shows that ECs suppress neuroinflammation more effectively than PWH on therapy. |
| Databáze: | OpenAIRE |
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