Immunomodulatory aspects in the progression and treatment of oral malignancy
| Autor: | Eiji Takayama, Yasunori Muramatsu, Shinichiro Sumitomo, Nobuo Kondoh, Masako Mizuno-Kamiya, Harumi Kawaki, Naoki Umemura, Kenji Mitsudo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Stromal cell medicine.medical_treatment Tumor associated macrophage (TAM) Article Programmed death ligand (PD-L)1 03 medical and health sciences Programmed death (PD)1 0302 clinical medicine Immune system Interferon Immune suppression Medicine Tumor microenvironment (TME) General Dentistry IFN-γ Tumor microenvironment business.industry Monocyte 030206 dentistry Cancer-associated fibroblast (CAF) medicine.disease Head and neck squamous-cell carcinoma Immune checkpoint lcsh:RK1-715 stomatognathic diseases 030104 developmental biology medicine.anatomical_structure Cytokine lcsh:Dentistry Cancer research IL-1α business medicine.drug |
| Zdroj: | Japanese Dental Science Review, Vol 55, Iss 1, Pp 113-120 (2019) The Japanese Dental Science Review |
| ISSN: | 1882-7616 |
| Popis: | Inflammation substantially affects the risk of oral malignancy. Pro-inflammatory cytokine, interferon (IFN)-γ, confers anti-tumor activity using several different mechanisms. Conversely, higher expression of interleukin (IL)-17 is associated with worse prognosis. Monocyte chemotactic protein (MCP)-1 correlates positively with poor long-term survival of head and neck squamous cell carcinoma (HNSCC) patients. IL-1α affects cancer associated fibroblasts and macrophages, and promote several malignant phenotypes including immune suppression. Some anti-inflammatory cytokines, including IL-10 and transforming growth factor (TGF)-β, relate to pro-tumoral activities.Among immune checkpoint modulators, programmed death (PD-)1 and PD-ligand (L)1 facilitate oral squamous cell carcinoma (OSCC) cell evasion from immune surveillance, and the expression status of these has a prognostic value.OSCCs contain tumor associated macrophages (TAMs) as major stromal cells of their tumor microenvironment. Among the two distinctive states, M2 macrophages support tumor invasion, metastasis and immune suppression. Crosstalk between TAMs and OSCC or cancer-associated fibroblasts (CAF) plays an important role in the progression of OSCC.Clinical trials with blocking antibodies against IL-1α or melanoma-associated antigens have been reported as therapeutic approaches against OSCCs. The most promising approach activating antitumor immunity is the blockade of PD-1/PD-L1 axis. Manipulating the polarization of pro-tumorigenic macrophages has been reported as a novel therapeutic approach. Keywords: Immune suppression, Tumor microenvironment (TME), IL-1α, IFN-γ, Programmed death (PD)1, Programmed death ligand (PD-L)1, Tumor associated macrophage (TAM), Cancer-associated fibroblast (CAF) |
| Databáze: | OpenAIRE |
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