Chronic kidney disease: pathological and functional assessment with diffusion tensor imaging at 3T MR
| Autor: | Ying Xu, Xianshun Yuan, Junhui Zhen, Qingwei Liu, Jie Zhang, Shifeng Cai, Rong Wang, Zhiling Liu |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Kidney Cortex Adolescent Biopsy Renal function urologic and male genital diseases Young Adult Cortex (anatomy) Fractional anisotropy medicine Effective diffusion coefficient Humans Radiology Nuclear Medicine and imaging Prospective Studies Renal Insufficiency Chronic Medulla business.industry General Medicine Middle Aged medicine.disease medicine.anatomical_structure Diffusion Tensor Imaging Renal pathology Anisotropy Female Radiology business Kidney disease Diffusion MRI Glomerular Filtration Rate |
| Zdroj: | European radiology. 25(3) |
| ISSN: | 1432-1084 |
| Popis: | Our objective was to evaluate pathological and functional changes in chronic kidney disease (CKD) using diffusion tensor imaging (DTI) at 3 T. There were fifty-one patients with CKD who required biopsy and 19 healthy volunteers who were examined using DTI at 3 T. The mean values of fractional anisotropy (FA) and the apparent diffusion coefficient (ADC) were obtained from the renal parenchyma (cortex and medulla). Correlations between imaging results and the estimated glomerular filtration rate (eGFR), as well as pathological damage (glomerular lesion and tubulointerstitial injury), were evaluated. The renal cortical FA was significantly lower than the medullary in both normal and affected kidneys (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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