Effects of ovariectomy on inputs from the medial preoptic area to the ventromedial nucleus of the hypothalamus of young adult rats

Autor: Lais da Silva Pereira, Susana Isabel Sá, Jozélia G. Ferreira, Denise Ribeiro Gobbo, José de Anchieta C. Horta-Júnior, Jackson C. Bittencourt
Přispěvatelé: Universidade de São Paulo (USP), Universidade Estadual Paulista (Unesp), Univ Porto
Rok vydání: 2020
Předmět:
0301 basic medicine
medicine.medical_specialty
puberty
Histology
Ovariectomy
Biology
Rats
Sprague-Dawley
03 medical and health sciences
0302 clinical medicine
Nerve Fibers
Internal medicine
Phaseolus vulgarisleucoagglutinin
medicine
Biological neural network
Animals
Young adult
Gonadal Steroid Hormones
Molecular Biology
Ecology
Evolution
Behavior and Systematics
three-dimensional reconstruction
COMPORTAMENTO SEXUAL ANIMAL
food and beverages
Phaseolus vulgaris leucoagglutinin
Cell Biology
Preoptic Area
Original Papers
Medial preoptic area
Sexual dimorphism
030104 developmental biology
Ventromedial nucleus of the hypothalamus
Endocrinology
Ventromedial Hypothalamic Nucleus
neural circuitry
Ovariectomized rat
Female
Anatomy
female sexual behaviour
030217 neurology & neurosurgery
Developmental Biology
Hormone
steroids
Zdroj: J Anat
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
ISSN: 1469-7580
Popis: Made available in DSpace on 2021-06-25T12:18:59Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-09-11 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Fundacao para a Ciencia e a Tecnologia Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Puberty is an important phase of development when the neural circuit organization is transformed by sexual hormones, inducing sexual dimorphism in adult behavioural responses. The principal brain area responsible for the control of the receptive component of female sexual behaviour is the ventrolateral division of the ventromedial nucleus of the hypothalamus (VMHvl), which is known for its dependency on ovarian hormones. Inputs to the VMHvl originating from the medial preoptic nucleus (MPN) are responsible for conveying essential information that will trigger such behaviour. Here, we investigated the pattern of the projection of the MPN to the VMHvl in rats ovariectomized at the onset of puberty. Sprague Dawley rats were ovariectomized (OVX) at puberty and then subjected to iontophoretic injections of the neuronal anterograde tracerPhaseolus vulgaris leucoagglutinininto the MPN once they reached 90 days of age. This study analysed the connectivity pattern established between the MPN and the VMH that is involved in the neuronal circuit responsible for female sexual behaviour in control and OVX rats. The data show the changes in the organization of the connections observed in the OVX adult rats that displayed a reduced axonal length for the MPN fibres reaching the VMHvl, suggesting that peripubertal ovarian hormones are relevant to the organization of MPN connections with structures involved in the promotion of female sexual behaviour. Univ Sao Paulo, Inst Ciencias Biomed, Lab Neuroanat Quim, Sao Paulo, Brazil Univ Estadual Paulista, Inst Biociencias Botucatu, Setor Anat, Dept Biol Estrutural & Func, Botucatu, SP, Brazil Univ Porto, Fac Med, Dept Biomed, Unit Anat, Porto, Portugal Univ Porto, Ctr Hlth Technol & Serv Res, CINTESIS, Fac Med, Porto, Portugal Univ Sao Paulo, Inst Psicol, Nucleo Neurociencias & Comportamento, Sao Paulo, Brazil Univ Estadual Paulista, Inst Biociencias Botucatu, Setor Anat, Dept Biol Estrutural & Func, Botucatu, SP, Brazil FAPESP: 2010/52068-0 FAPESP: 2015/059904 FAPESP: 2016/02224-1 FAPESP: 2016/13136-6 Fundacao para a Ciencia e a Tecnologia: UID/IC/4255/2013 CAPES: 848/15 CNPq: 426378/2016-4
Databáze: OpenAIRE
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