Impaired cellular immune response in rats exposed perinatally to Baltic Sea herring oil or 2,3,7,8-TCDD
| Autor: | Helen van der Vliet, Jan Groen, Peter S. Ross, Ineke Schipholt, D.C. Morse, Abraham Brouwer, Arja de Klerk, Rik L. de Swart, Linette Willemsen, Geert van Amerongen, Joseph G. Vos, Albert D. M. E. Osterhaus, Henk Van Loveren |
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| Přispěvatelé: | Virology |
| Rok vydání: | 1997 |
| Předmět: |
Baltic States
Male Polychlorinated Dibenzodioxins Health Toxicology and Mutagenesis Lymphocyte Physiology Thymus Gland Immunotoxicology 8-tetrachlorodibenzo-p-dioxin (TCDD) Toxicology Fish Oils Herring Immune system Pregnancy Lactation medicine Animals Hypersensitivity Delayed Toxicologie Immunity Cellular Polychlorinated biphenyls (PCBs) Atlantic herring biology Food chain Fishes General Medicine biology.organism_classification Fish oil Immunity Innate Rats Killer Cells Natural Thyroxine Host resistance medicine.anatomical_structure Immune System Prenatal Exposure Delayed Effects Cytomegalovirus Infections Toxicity Female 2 3 7 8-tetrachlorodibenzo-p-dioxin (TCDD) Spleen Water Pollutants Chemical |
| Zdroj: | Archives of Toxicology 17 (1997) Archives of Toxicology, 17, 563-574 Archives of Toxicology, 17, 563-574. Springer-Verlag |
| ISSN: | 0340-5761 |
| Popis: | While the immunotoxicity of 2,3,7,8-tetrachlo- rodibenzo-p-dioxin (TCDD) has been well established, the eAects of complex environmental mixtures of poly- halogenated aromatic hydrocarbons (PHAHs) are poorly understood. Many PHAHs, including the poly- chlorinated-biphenyls (PCBs), -dibenzofurans (PCDFs), and dibenzo-p-dioxins (PCDDs), possess 'dioxin-like' activities, and accumulate in the aquatic food chain. Organisms occupying high trophic levels may therefore be exposed to concentrations which may present an immunotoxic risk. In this study, pregnant PVG rats were administered a daily oral dose of 1 ml of the following during pregnancy and lactation: (1) oil extracted from herring caught in the relatively uncontaminated Atlantic Ocean; (2) oil extracted from herring caught in the contaminated Baltic Sea; or (3) the Atlantic herring oil extract spiked with 2,3,7,8-TCDD. The daily intakes of aryl hydrocarbon (Ah)-receptor dependent toxic equiv- alents (TEQ) for mothers were 0.3 in the Atlantic group, 2.1 in the Baltic group, and 134 ng/kg body wt. in the 2,3,7,8-TCDD positive control group. Immune function and host resistance to rat cytomegalovirus (RCMV) were assessed in oAspring aged 11, 25, 46 or 59 days. Rat pups in the positive control TCDD-spiked group exhibited immunosuppression characterized by reduced thymus weight and cellularity, reduced thymocyte and splenocyte proliferative responses to T-dependent mi- togens in vitro, reduced virus-associated natural killer (NK) cell and specific antibody responses. While less pronounced, a similar pattern of eAects was observed in the rat pups exposed only to the Baltic Sea herring oil. These immunotoxic eAects were transient in both ex- posure groups, with a time-related recovery in immune function possibly due to the half-life of TCDD in rats and the waning exposure levels in the rapidly growing pups. We previously demonstrated that the same Baltic Sea herring led to impaired natural killer cell and T- lymphocyte function in harbour seals during the course of a long-term captive feeding study. The collective re- sults of these studies in rats and seals indicate the immunotoxic potential of environmental mixtures at current levels in the aquatic environment, and suggest that the developing immune system of young mammals may be at particular risk. |
| Databáze: | OpenAIRE |
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