Serum Levels of IL-6, IL-8, TNF-α, and TGF-β in Chronic HBV-Infected Patients: Effect of Depression and Anxiety
| Autor: | Hassan Yousefidaredor, Amin Safari Arababadi, Mehdi Khaleghinia, Reza Bahramabadi, Seyyed Mohammad Hashemi, Yaser Eskandari Torbaghan, Mohammad Hossein Bakhshi, Mahmood Sheikh Fathollahi, Yaser Yousefpoor, Mohammad Kazemi Arababadi, Reza Bidaki, Minoo Safari Arababadi |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult medicine.medical_specialty medicine.medical_treatment Clinical Biochemistry Inflammation Anxiety medicine.disease_cause Gastroenterology 03 medical and health sciences 0302 clinical medicine Hepatitis B Chronic Internal medicine Medicine Humans Interleukin 8 Interleukin 6 Depression (differential diagnoses) Hepatitis B virus biology business.industry Depression Biochemistry (medical) Interleukin Middle Aged 030104 developmental biology Cytokine Cross-Sectional Studies biology.protein Cytokines Tumor necrosis factor alpha medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Laboratory medicine. 49(1) |
| ISSN: | 1943-7730 |
| Popis: | Objective To assess the effects of depression and anxiety on serum cytokine levels in patients with chronic hepatitis B (CHB) infection. Methods In this cross-sectional study, 60 healthy control individuals and 60 patients with CHB participated after filling out standard questionnaires. We examined their serum interleukin (IL)-6, IL-8, tumor necrosis factor (TNF)-α, and TGF-β levels using enzyme-linked immunosorbent assay (ELISA) techniques. Results In patients with CHB compared with healthy controls, serum levels of IL-8 were significantly increased, whereas IL-6 and TGF-β levels were significantly decreased. Serum levels of TGF-β were significantly decreased in the patients with CHB who had mild depression, compared with patients with CHB without depression and with moderate and severe depression. Conclusions Downregulation of IL-8 and TGF-β, respectively, is a corresponding mechanism for induction of chronic inflammation in patients with CHB. Depression also seems to induce inflammation via downregulation of TGF-β in these patients. |
| Databáze: | OpenAIRE |
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