Capsular polysaccharide from a fish-gut bacterium induces/promotes apoptosis of colon cancer cells in vitro through Caspases' pathway activation
| Autor: | Maria Michela Corsaro, Chiara Schiraldi, Angela Casillo, Soichiro Kawai, Celeste Di Meo, Antonietta Stellavato, Jun Kawamoto, Tatsuo Kurihara, Rossella Di Guida, Takuya Ogawa |
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| Přispěvatelé: | Di Guida, R., Casillo, A., Stellavato, A., Kawai, S., Ogawa, T., Di Meo, C., Kawamoto, J., Kurihara, T., Schiraldi, C., Corsaro, M. M., Di Guida, Rossella, Casillo, Angela, Stellavato, Antonietta, Kawai, Soichiro, Ogawa, Takuya, DI MEO, Celeste, Kawamoto, Jun, Kurihara, Tatsuo, Schiraldi, Chiara, Michela Corsaro, Maria |
| Rok vydání: | 2021 |
| Předmět: |
Structural determination
Polymers and Plastics Colorectal cancer Cell Survival medicine.medical_treatment Cold-adapted bacterium Antineoplastic Agents Apoptosis Polysaccharide Molecular weight Polysaccharides Materials Chemistry medicine Tumor Cells Cultured Humans Pseudoalteromonas nigrifaciens Caspase Cell Proliferation chemistry.chemical_classification Chemotherapy biology Anti-cancer Organic Chemistry Immunotherapy biology.organism_classification medicine.disease Bioinformatic analysi In vitro Pseudoalteromonas chemistry Caspases Colonic Neoplasms Cancer research biology.protein Capsular polysaccharide Drug Screening Assays Antitumor |
| Zdroj: | Carbohydrate polymers. 278 |
| ISSN: | 1879-1344 |
| Popis: | Among the widespread malignancies colorectal cancer is the most lethal. Treatments of this malignant tumor include surgery for lesions and metastases, radiotherapy, immunotherapy, and chemotherapy. Nevertheless, novel therapies to reduce morbidity and mortality are demanding. Natural products, such as polysaccharides, can be a valuable alternative to sometimes very toxic chemotherapeutical agents, also because they are biocompatible and biodegradable biomaterials. Microbial polysaccharides have been demonstrated to fulfill this requirement. In this paper, the results about the structure and the activity of a capsular polysaccharide isolated from the psychrotroph Pseudoalteromonas nigrifaciens Sq02-Rifr, newly isolated from the fish intestine, have been described. The characterization has been obtained by spectroscopic and chemical methods, and it is supported by the bioinformatic analysis. The polymer activates Caspases 3 and 9 on colon cancer cells CaCo-2 and HCT-116, indicating a promising antitumor effect, and suggesting a potential capacity of CPS to induce apoptosis. |
| Databáze: | OpenAIRE |
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