Effect of Lycopene on Doxorubicin-Induced Cardiotoxicity: An Echocardiographic, Histological and Morphometrical Assessment

Autor: Mirna Matsui, Marcelo Sady Plácido Ladeira, Robert M. Russell, Daisy Maria Favero Salvadori, Ana Lúcia dos Anjos Ferreira, Beatriz Bojikian Matsubara, Maria Carolina Munhoz Oliveira Nascimento, Guangwen Tang, Noeme Sousa Rocha, Luiz Shiguero Matsubara, Flávio A. Carvalho
Přispěvatelé: Universidade Estadual Paulista (Unesp), Tufts Univ
Rok vydání: 2007
Předmět:
Zdroj: Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
ISSN: 1742-7843
1742-7835
DOI: 10.1111/j.1742-7843.2007.00070.x
Popis: Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2014-02-26T17:29:57Z No. of bitstreams: 1 WOS000247681900003.pdf: 188914 bytes, checksum: 5ce9b5e62ee21d4e1a89f15824da88f4 (MD5) Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2014-02-26T17:29:57Z No. of bitstreams: 1 WOS000247681900003.pdf: 188914 bytes, checksum: 5ce9b5e62ee21d4e1a89f15824da88f4 (MD5) Made available in DSpace on 2014-02-26T17:29:57Z (GMT). No. of bitstreams: 1 WOS000247681900003.pdf: 188914 bytes, checksum: 5ce9b5e62ee21d4e1a89f15824da88f4 (MD5) Previous issue date: 2007-07-01 Made available in DSpace on 2014-02-26T17:29:57Z (GMT). No. of bitstreams: 1 WOS000247681900003.pdf: 188914 bytes, checksum: 5ce9b5e62ee21d4e1a89f15824da88f4 (MD5) Previous issue date: 2007-07-01 Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2014-02-26T17:29:57Z No. of bitstreams: 1 WOS000247681900003.pdf: 188914 bytes, checksum: 5ce9b5e62ee21d4e1a89f15824da88f4 (MD5) Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:37:02Z No. of bitstreams: 1 WOS000247681900003.pdf: 188914 bytes, checksum: 5ce9b5e62ee21d4e1a89f15824da88f4 (MD5) Made available in DSpace on 2014-02-26T17:29:57Z (GMT). No. of bitstreams: 1 WOS000247681900003.pdf: 188914 bytes, checksum: 5ce9b5e62ee21d4e1a89f15824da88f4 (MD5) Previous issue date: 2007-07-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:37:02Z No. of bitstreams: 1 WOS000247681900003.pdf: 188914 bytes, checksum: 5ce9b5e62ee21d4e1a89f15824da88f4 (MD5) Made available in DSpace on 2014-02-26T17:29:57Z (GMT). No. of bitstreams: 1 WOS000247681900003.pdf: 188914 bytes, checksum: 5ce9b5e62ee21d4e1a89f15824da88f4 (MD5) Previous issue date: 2007-07-01 Made available in DSpace on 2014-05-20T13:37:02Z (GMT). No. of bitstreams: 1 WOS000247681900003.pdf: 188914 bytes, checksum: 5ce9b5e62ee21d4e1a89f15824da88f4 (MD5) Previous issue date: 2007-07-01 Made available in DSpace on 2014-05-20T13:37:02Z (GMT). No. of bitstreams: 1 WOS000247681900003.pdf: 188914 bytes, checksum: 5ce9b5e62ee21d4e1a89f15824da88f4 (MD5) Previous issue date: 2007-07-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:37:02Z No. of bitstreams: 1 WOS000247681900003.pdf: 188914 bytes, checksum: 5ce9b5e62ee21d4e1a89f15824da88f4 (MD5) Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:37:02Z No. of bitstreams: 1 WOS000247681900003.pdf: 188914 bytes, checksum: 5ce9b5e62ee21d4e1a89f15824da88f4 (MD5) Made available in DSpace on 2014-05-20T13:37:02Z (GMT). No. of bitstreams: 1 WOS000247681900003.pdf: 188914 bytes, checksum: 5ce9b5e62ee21d4e1a89f15824da88f4 (MD5) Previous issue date: 2007-07-01 Made available in DSpace on 2014-05-20T13:37:02Z (GMT). No. of bitstreams: 1 WOS000247681900003.pdf: 188914 bytes, checksum: 5ce9b5e62ee21d4e1a89f15824da88f4 (MD5) Previous issue date: 2007-07-01 Doxorubicin is an excellent chemotherapeutic agent utilized for several types of cancer but the irreversible doxorubicin-induced cardiac damage is the major limitation for its use. Oxidative stress seems to be associated with some phase of the toxicity mechanism process. To determine if lycopene protects against doxorubicin-induced cardiotoxicity, male Wistar rats were randomly assigned either to control, lycopene, doxorubicin or doxorubicin + lycopene groups. They received corn oil (control, doxorubicin) or lycopene (5 mg/kg body weight a day) (lycopene, doxorubicin + lycopene) by gavage for a 7-week period. They also received saline (control, lycopene) or doxorubicin (4 mg/kg) (doxorubicin, doxorubin + lycopene) intraperitoneally by week 3, 4 5 and 6. Animals underwent echocardiogram and were killed for tissue analyses by week 7. Mean lycopene levels (nmol/kg) in liver were higher in the doxorubicin + lycopene group (5822.59) than in the lycopene group (2496.73), but no differences in lycopene were found in heart or Plasma of these two groups. Lycopene did not prevent left ventricular systolic dysfunction induced by doxorubicin. However, morphologic examination revealed that doxorubicin-induced myocyte damage was significantly suppressed in rats treated with lycopene. Doxorubicin treatment was followed by increase of myocardium interstitial collagen volume fraction. Our results show that: (i) doxorubicin-induced cardiotoxicity was confirmed by echocardiogram and morphological evaluations; (ii) lycopene absorption was confirmed by its levels in heart, liver and plasma; (iii) lycopene supplementation provided myocyte protection without preventing interstitial collagen accumulation increase; (iv) doxorubicin-induced cardiac dysfunction was not prevented by lycopene supplementation; and (v) lycopene depletion was not observed in plasma and tissues from animals treated with doxorubicin. Univ Estadual Paulista, Botucatu Fac Med, Dept Internal Med, Botucatu, SP, Brazil Univ Estadual Paulista, Botucatu Fac Med, Dept Pathol, Botucatu, SP, Brazil Tufts Univ, USDA, Human Nutr Res Ctr Aging, Boston, MA 02111 USA Univ Estadual Paulista, Botucatu Fac Med, Dept Internal Med, Botucatu, SP, Brazil Univ Estadual Paulista, Botucatu Fac Med, Dept Pathol, Botucatu, SP, Brazil
Databáze: OpenAIRE
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